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Loxl3 Gene Detail
Summary
  • Symbol
    Loxl3
  • Name
    lysyl oxidase-like 3
  • Synonyms
    Lor2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337004
    NCBI Gene: 16950
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83011186-83029547 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    359 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337004
protein coding gene Chr6:83011154-83029547 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030910
protein coding gene Chr6:84036854-84056245 (+)
A/J MGP_AJ_G0030879
protein coding gene Chr6:80822895-80842911 (+)
AKR/J MGP_AKRJ_G0030807
protein coding gene Chr6:83153998-83172366 (+)
BALB/cJ MGP_BALBcJ_G0030889
protein coding gene Chr6:80837276-80855866 (+)
C3H/HeJ MGP_C3HHeJ_G0030821
protein coding gene Chr6:101211290-101229513 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031349
protein coding gene Chr6:86316328-86335612 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028535
protein coding gene Chr6:79182979-79201596 (+)
CAST/EiJ MGP_CASTEiJ_G0029998
protein coding gene Chr6:83152235-83172459 (+)
CBA/J MGP_CBAJ_G0030576
protein coding gene Chr6:89729643-89747885 (+)
DBA/2J MGP_DBA2J_G0030729
protein coding gene Chr6:80144276-80162520 (+)
FVB/NJ MGP_FVBNJ_G0030682
protein coding gene Chr6:79351079-79370237 (+)
LP/J MGP_LPJ_G0030808
protein coding gene Chr6:84029766-84050145 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030718
protein coding gene Chr6:94032741-94052643 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031373
protein coding gene Chr6:82966352-82985115 (+)
PWK/PhJ MGP_PWKPhJ_G0029713
protein coding gene Chr6:79035008-79054715 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029541
protein coding gene Chr6:81810562-81831626 (+)
WSB/EiJ MGP_WSBEiJ_G0030079
protein coding gene Chr6:83406359-83424702 (+)



Homology
more
  • Human Ortholog
    LOXL3, lysyl oxidase like 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LOXL3, lysyl oxidase like 3
  • Synonyms
    LOXL, MYP28
  • Links
    NCBI Gene ID: 84695
    neXtProt AC: NX_P58215
    UniProt: P58215

  • Chr Location
    2p13.1; chr2:74532258-74555702 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human LOXL3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality shortly after birth, craniofacial and vertebral abnormalities associated with collagen deformities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16950 NCBI Gene Model | MGI Sequence Detail 18362 C57BL/6J ±  kb
    transcript NM_013586 RefSeq | MGI Sequence Detail 4070 ZRU/MplStud  
    polypeptide Q9Z175 UniProt | EBI | MGI Sequence Detail 754 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 3
      cDNA 8
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:52798 Jang W, et al., Comparative sequence of human and mouse BAC clones from the mnd2 region of chromosome 2p13. Genome Res. 1999 Jan;9(1):53-61
    • Latest
      J:337013 Melamed S, et al., Initiation of fibronectin fibrillogenesis is an enzyme-dependent process. Cell Rep. 2023 May 30;42(5):112473

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/22/2024
    MGI 6.24
    The Jackson Laboratory