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Zfand5 Gene Detail
Summary
  • Symbol
    Zfand5
  • Name
    zinc finger, AN1-type domain 5
  • Synonyms
    2310057A04Rik, 5830475F03Rik, Za20d2, Zfp216
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278334
    NCBI Gene: 22682
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:21249642-21264204 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 14.32 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    409 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1278334
 protein coding gene Chr19:21249150-21264204 (+)
129S1/SvImJ ENSMUSG00200020583
 protein coding gene Chr19:17997446-18012009 (+)
A/J ENSMUSG00195016547
 protein coding gene Chr19:18122297-18136858 (+)
AKR/J ENSMUSG00220010506
 protein coding gene Chr19:18098504-18113056 (+)
BALB/cJ ENSMUSG00180018111
 protein coding gene Chr19:18470609-18485161 (+)
C3H/HeJ ENSMUSG00175003346
 protein coding gene Chr19:17831018-17845581 (+)
C57BL/6NJ ENSMUSG00215016839
 protein coding gene Chr19:17857168-17871731 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022813
 protein coding gene Chr19:18488783-18498836 (+)
CAST/EiJ ENSTCUG00005008260
 protein coding gene Chr19:17718510-17733045 (+)
CBA/J ENSMUSG00210012738
 protein coding gene Chr19:18071231-18085793 (+)
DBA/2J ENSMUSG00185013636
 protein coding gene Chr19:18457363-18471925 (+)
FVB/NJ ENSMUSG00205003832
 protein coding gene Chr19:17875417-17889979 (+)
JF1/MsJ ENSUMUG00000034295
 protein coding gene Chr19:18687727-18702214 (+)
LP/J ENSMUSG00230020418
 protein coding gene Chr19:19311849-19326411 (+)
NOD/ShiLtJ ENSMUSG00190019364
 protein coding gene Chr19:17843680-17858242 (+)
NZO/HlLtJ ENSMUSG00225034202
 protein coding gene Chr19:23056532-23071021 (+)
PWK/PhJ ENSLUMG00010008458
 protein coding gene Chr19:18002438-18016914 (+)
SPRET/EiJ ENSMSPG00010017655
 protein coding gene Chr19:18005913-18015444 (+)
WSB/EiJ ENSIUOG00005007029
 protein coding gene Chr19:17565090-17579652 (+)



Homology
more
  • Human Ortholog
    ZFAND5, zinc finger AN1-type containing 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFAND5, zinc finger AN1-type containing 5
  • Synonyms
    ZA20D2, ZFAND5A, ZNF216
  • Links
    NCBI Gene ID: 7763
    UniProt: O76080

  • Chr Location
    9q21.13; chr9:72351412-72365328 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display resistance to age related obesity and resistance to induced muscular atrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    118
  • cDNA Data
    22
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024750 Ensembl Gene Model | MGI Sequence Detail 14563 C57BL/6J ±  kb
    transcript ENSMUST00000237651 Ensembl | MGI Sequence Detail 7385 Not Applicable  
    polypeptide ENSMUSP00000158187 Ensembl | MGI Sequence Detail 213 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 24
      Primer pair 1
      Other 1

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGI:1919194, MGI:1923353, MGI:2145558
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 9
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:49546 Scott DA, et al., Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19. Gene. 1998 Jul 30;215(2):461-9
    • Latest
      J:380602 Lee D, et al., Molecular mechanism for activation of the 26S proteasome by ZFAND5. Mol Cell. 2023 Aug 17;83(16):2959-2975.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory