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Bcl6b Gene Detail
Summary
  • Symbol
    Bcl6b
  • Name
    B cell CLL/lymphoma 6, member B
  • Synonyms
    Bazf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278332
    NCBI Gene: 12029
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70114954-70120624 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.99 cM, cytoband B4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1278332
protein coding gene Chr11:70114953-70120624 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018586
protein coding gene Chr11:70744665-70750339 (-)
A/J MGP_AJ_G0018554
protein coding gene Chr11:68055983-68061653 (-)
AKR/J MGP_AKRJ_G0018523
protein coding gene Chr11:70086465-70092135 (-)
BALB/cJ MGP_BALBcJ_G0018526
protein coding gene Chr11:68378759-68384429 (-)
C3H/HeJ MGP_C3HHeJ_G0018339
protein coding gene Chr11:70124830-70130500 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018977
protein coding gene Chr11:72842769-72848439 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016622
protein coding gene Chr11:64974526-64980213 (-)
CAST/EiJ MGP_CASTEiJ_G0017894
protein coding gene Chr11:70370431-70376114 (-)
CBA/J MGP_CBAJ_G0018311
protein coding gene Chr11:76153128-76158798 (-)
DBA/2J MGP_DBA2J_G0018421
protein coding gene Chr11:67631715-67637390 (-)
FVB/NJ MGP_FVBNJ_G0018411
protein coding gene Chr11:67287231-67292901 (-)
LP/J MGP_LPJ_G0018491
protein coding gene Chr11:71314367-71320037 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018434
protein coding gene Chr11:76721287-76726961 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019019
protein coding gene Chr11:70358266-70363936 (-)
PWK/PhJ MGP_PWKPhJ_G0017668
protein coding gene Chr11:68285301-68290965 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017458
protein coding gene Chr11:70156118-70161804 (-)
WSB/EiJ MGP_WSBEiJ_G0017948
protein coding gene Chr11:70021696-70027369 (-)



Homology
more
  • Human Ortholog
    BCL6B, BCL6B transcription repressor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCL6B, BCL6B transcription repressor
  • Synonyms
    BAZF, ZBTB28, ZNF62
  • Links
    NCBI Gene ID: 255877
    neXtProt AC: NX_Q8N143
    UniProt: Q8N143

  • Chr Location
    17p13.1; chr17:7023050-7030290 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Targeted
    8
  • Transgenic
    1
  • Genomic Mutations
    3 involving Bcl6b
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Homozygous null mice display decreased CD4+ and CD8+ cell numbers in the thymus. Homozygous mice for one null allele display decreased secondary responses of memory CD8+ T cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000317 Ensembl Gene Model | MGI Sequence Detail 5671 C57BL/6J ±  kb
transcript ENSMUST00000000326 Ensembl | MGI Sequence Detail 3366 Not Applicable  
polypeptide ENSMUSP00000000326 Ensembl | MGI Sequence Detail 474 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    Genomic 1
    cDNA 20
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 55
    Developmental Gene Expression 10
    Gene Ontology 4
    Phenotypes 20
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory