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Hs3st1 Gene Detail
Summary
  • Symbol
    Hs3st1
  • Name
    heparan sulfate (glucosamine) 3-O-sulfotransferase 1
  • Synonyms
    3-OST, D5Wsu110e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201606
    NCBI Gene: 15476
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:39771278-39802791 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 21.14 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    926 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201606
 protein coding gene Chr5:39771278-39912818 (-)
129S1/SvImJ ENSMUSG00200028790
 protein coding gene Chr5:35223312-35254554 (-)
A/J ENSMUSG00195028535
 protein coding gene Chr5:34678953-34710293 (-)
AKR/J ENSMUSG00220002234
 protein coding gene Chr5:34706030-34737363 (-)
BALB/cJ ENSMUSG00180021371
 protein coding gene Chr5:34481691-34513027 (-)
C3H/HeJ ENSMUSG00175017307
 protein coding gene Chr5:36472149-36503479 (-)
C57BL/6NJ ENSMUSG00215005489
 protein coding gene Chr5:35223562-35254877 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027185
 protein coding gene Chr5:34418637-34554568 (-)
CAST/EiJ ENSTCUG00005022936
 protein coding gene Chr5:34648122-34679261 (-)
CBA/J ENSMUSG00210003477
 protein coding gene Chr5:35440058-35471398 (-)
DBA/2J ENSMUSG00185016262
 protein coding gene Chr5:37307339-37338583 (-)
FVB/NJ ENSMUSG00205014789
 protein coding gene Chr5:34239071-34270318 (-)
JF1/MsJ ENSUMUG00000001356
 protein coding gene Chr5:41852505-41883687 (-)
LP/J ENSMUSG00230002530
 protein coding gene Chr5:41949444-41980685 (-)
NOD/ShiLtJ ENSMUSG00190003057
 protein coding gene Chr5:34495901-34527138 (-)
NZO/HlLtJ ENSMUSG00225016345
 protein coding gene Chr5:47107281-47138546 (-)
PWK/PhJ ENSLUMG00010021590
 protein coding gene Chr5:34519682-34550903 (-)
SPRET/EiJ ENSMSPG00010029723
 protein coding gene Chr5:35806767-35837994 (-)
WSB/EiJ ENSIUOG00005016384
 protein coding gene Chr5:37391564-37422854 (-)



Homology
more
  • Human Ortholog
    HS3ST1, heparan sulfate-glucosamine 3-sulfotransferase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HS3ST1, heparan sulfate-glucosamine 3-sulfotransferase 1
  • Synonyms
    3OST, 3OST1
  • Links
    NCBI Gene ID: 9957
    UniProt: O14792

  • Chr Location
    4p15.33; chr4:11393150-11434327 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    6 involving Hs3st1
  • Incidental Mutations
    Mutagenetix
  • Find Mice (IMSR)
    18 strains or lines available
Homozygous mutation of this gene results in embryonic growth retardation and death between postnatal days 2-3 when bred on a C57BL/6J background. Mice homozygous for this mutation on a 129 background are normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    148
  • cDNA Data
    47
  • Literature Summary
    13
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15476 NCBI Gene Model | MGI Sequence Detail 31514 C57BL/6J ±  kb
transcript NM_001421581 RefSeq | MGI Sequence Detail 1865 ZRU/MplStud  
polypeptide O35310 UniProt | EBI | MGI Sequence Detail 311 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 47
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-34175, MGI:106481
References
more
  • Summaries
    All 78
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 15
    Phenotypes 29
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:375079 Clausen TM, et al., Antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and suppresses pancreatic tumorigenesis. J Clin Invest. 2025 Nov 17;135(22)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory