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Ogn Gene Detail
Summary
  • Symbol
    Ogn
  • Name
    osteoglycin
  • Synonyms
    3110079A16Rik, mimecan, mimican, OG, SLRR3A
  • Feature Type
    protein coding gene
  • IDs
    MGI:109278
    NCBI Gene: 18295
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:49761522-49777977 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 25.34 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    263 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109278
 protein coding gene Chr13:49761491-49777977 (+)
129S1/SvImJ ENSMUSG00200034835
 protein coding gene Chr13:47040373-47056828 (+)
A/J ENSMUSG00195029360
 protein coding gene Chr13:46090068-46106523 (+)
AKR/J ENSMUSG00220008648
 protein coding gene Chr13:45906284-45922740 (+)
BALB/cJ ENSMUSG00180008269
 protein coding gene Chr13:46392341-46408798 (+)
C3H/HeJ ENSMUSG00175026643
 protein coding gene Chr13:46362769-46379223 (+)
C57BL/6NJ ENSMUSG00215005062
 protein coding gene Chr13:46509325-46525778 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018508
 protein coding gene Chr13:44830517-44847478 (+)
CAST/EiJ ENSTCUG00005030378
 protein coding gene Chr13:46424067-46440534 (+)
CBA/J ENSMUSG00210027028
 protein coding gene Chr13:46368149-46384604 (+)
DBA/2J ENSMUSG00185031140
 protein coding gene Chr13:47182162-47198617 (+)
FVB/NJ ENSMUSG00205010325
 protein coding gene Chr13:46150869-46167324 (+)
JF1/MsJ ENSUMUG00000014524
 protein coding gene Chr13:46714186-46730656 (+)
LP/J ENSMUSG00230028852
 protein coding gene Chr13:56502940-56519395 (+)
NOD/ShiLtJ ENSMUSG00190011604
 protein coding gene Chr13:46587024-46603479 (+)
NZO/HlLtJ ENSMUSG00225035810
 protein coding gene Chr13:50253318-50269773 (+)
PWK/PhJ ENSLUMG00010020629
 protein coding gene Chr13:45568420-45585102 (+)
SPRET/EiJ ENSMSPG00010029245
 protein coding gene Chr13:45704781-45721413 (+)
WSB/EiJ ENSIUOG00005026770
 protein coding gene Chr13:45733260-45749728 (+)



Homology
more
  • Human Ortholog
    OGN, osteoglycin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OGN, osteoglycin
  • Synonyms
    OG, OIF, SLRR3A
  • Links
    NCBI Gene ID: 4969
    UniProt: P20774

  • Chr Location
    9q22.31; chr9:92383268-92406734 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display reduced collagen fiber density and organization, as well as more variability in fibrilar diameter in both the skin and the cornea. Corneal clarity was unaffected whereas skin tensile strength was reduced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1013
  • Tissues
    70
  • cDNA Data
    18
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021390 Ensembl Gene Model | MGI Sequence Detail 16456 C57BL/6J ±  kb
    transcript ENSMUST00000021822 Ensembl | MGI Sequence Detail 2566 Not Applicable  
    polypeptide ENSMUSP00000021822 Ensembl | MGI Sequence Detail 298 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 19
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38323, MGI:1920487
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 23
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:390354 Mori K, et al., Muscle-derived Mimecan regulates hypothalamus-brown adipose tissue communication and promotes health and lifespan in mice. Cell Metab. 2026 Jul 7;38(7):1425-1442.e9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory