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Loxl1 Gene Detail
Summary
  • Symbol
    Loxl1
  • Name
    lysyl oxidase-like 1
  • Synonyms
    LOXL
  • Feature Type
    protein coding gene
  • IDs
    MGI:106096
    NCBI Gene: 16949
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:58195021-58220469 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.65 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    770 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106096
 protein coding gene Chr9:58195006-58220495 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034889
 protein coding gene Chr9:57569875-57600340 (-)
A/J MGP_AJ_G0034870
 protein coding gene Chr9:55702321-55727941 (-)
AKR/J MGP_AKRJ_G0034799
 protein coding gene Chr9:57001705-57029108 (-)
BALB/cJ MGP_BALBcJ_G0034862
 protein coding gene Chr9:55473773-55499308 (-)
C3H/HeJ MGP_C3HHeJ_G0034572
 protein coding gene Chr9:57484459-57509927 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035381
 protein coding gene Chr9:59185515-59216805 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032292
 protein coding gene Chr9:54981826-55007670 (-)
CAST/EiJ MGP_CASTEiJ_G0033893
 protein coding gene Chr9:57569176-57594701 (-)
CBA/J MGP_CBAJ_G0034543
 protein coding gene Chr9:61258708-61287331 (-)
DBA/2J MGP_DBA2J_G0034702
 protein coding gene Chr9:55556050-55581831 (-)
FVB/NJ MGP_FVBNJ_G0034644
 protein coding gene Chr9:54792748-54820078 (-)
LP/J MGP_LPJ_G0034785
 protein coding gene Chr9:57856751-57882172 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034687
 protein coding gene Chr9:62708412-62738300 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035403
 protein coding gene Chr9:57012871-57038287 (-)
PWK/PhJ MGP_PWKPhJ_G0033598
 protein coding gene Chr9:55606521-55632970 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033432
 protein coding gene Chr9:57297172-57323759 (-)
WSB/EiJ MGP_WSBEiJ_G0034006
 protein coding gene Chr9:56962591-56989524 (-)



Homology
more
  • Human Ortholog
    LOXL1, lysyl oxidase like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LOXL1, lysyl oxidase like 1
  • Synonyms
    LOL, LOXL
  • Links
    NCBI Gene ID: 4016
    neXtProt AC: NX_Q08397
    UniProt: Q08397

  • Chr Location
    15q24.1; chr15:73925989-73952137 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Loxl1 mouse models; 3 with human LOXL1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 8 alleles in 8 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Elastic fiber homeostasis is disrupted in homozygous mutant mice, resulting in loose skin, abnormal lung morphology, intestinal defects, and post partum uterine prolapse.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    39
  • cDNA Data
    75
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032334 Ensembl Gene Model | MGI Sequence Detail 25449 C57BL/6J ±  kb
    transcript ENSMUST00000061799 Ensembl | MGI Sequence Detail 3297 Not Applicable  
    polypeptide ENSMUSP00000057406 Ensembl | MGI Sequence Detail 607 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 79
      Genomic 1
      cDNA 76
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33782
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 12
      Phenotypes 27
    • Earliest
      J:32426 Zuberi AR, et al., A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex. Genomics. 1996 Apr 1;33(1):75-84
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory