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Ptpn3 Gene Detail
Summary
  • Symbol
    Ptpn3
  • Name
    protein tyrosine phosphatase, non-receptor type 3
  • Synonyms
    9530011I20Rik, PTPCL, PTP-H1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105307
    NCBI Gene: 545622
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:57190841-57301837 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 31.66 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2747 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105307
 protein coding gene Chr4:57190841-57339036 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028316
 protein coding gene Chr4:55972458-56085355 (-)
A/J MGP_AJ_G0028277
 protein coding gene Chr4:53841257-53953533 (-)
AKR/J MGP_AKRJ_G0028226
 protein coding gene Chr4:55328406-55440533 (-)
BALB/cJ MGP_BALBcJ_G0028296
 protein coding gene Chr4:53993793-54106073 (-)
C3H/HeJ MGP_C3HHeJ_G0028017
 protein coding gene Chr4:55832836-55946915 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028737
 protein coding gene Chr4:57972106-58084846 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026043
 protein coding gene Chr4:50635326-50746910 (-)
CAST/EiJ MGP_CASTEiJ_G0027455
 protein coding gene Chr4:55536077-55664285 (-)
CBA/J MGP_CBAJ_G0027982
 protein coding gene Chr4:59969274-60086512 (-)
DBA/2J MGP_DBA2J_G0028132
 protein coding gene Chr4:53740880-53852822 (-)
FVB/NJ MGP_FVBNJ_G0028099
 protein coding gene Chr4:52963722-53083421 (-)
LP/J MGP_LPJ_G0028231
 protein coding gene Chr4:56084350-56193999 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028123
 protein coding gene Chr4:63109866-63226920 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028773
 protein coding gene Chr4:55507012-55621458 (-)
PWK/PhJ MGP_PWKPhJ_G0027180
 protein coding gene Chr4:53732729-53847312 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027008
 protein coding gene Chr4:54771764-54895877 (-)
WSB/EiJ MGP_WSBEiJ_G0027533
 protein coding gene Chr4:55462244-55576894 (-)



Homology
more
  • Human Ortholog
    PTPN3, protein tyrosine phosphatase non-receptor type 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPN3, protein tyrosine phosphatase non-receptor type 3
  • Synonyms
    PTP-H1, PTPH1
  • Links
    NCBI Gene ID: 5774
    neXtProt AC: NX_P26045
    UniProt: P26045

  • Chr Location
    9q31.3; chr9:109375466-109538420 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 4 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased body weight, especially in males, and male mice exhibit increased bone mineral content.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    21
  • cDNA Data
    36
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038764 Ensembl Gene Model | MGI Sequence Detail 110997 C57BL/6J ±  kb
    transcript ENSMUST00000075637 Ensembl | MGI Sequence Detail 6369 Not Applicable  
    polypeptide ENSMUSP00000075063 Ensembl | MGI Sequence Detail 913 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 36
      Other 1

      Microarray probesets 13
    Other
    Accession IDs
    less
    MGD-MRK-32348, MGI:3026925
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:30499 Messerle M, et al., Dynamic changes in gene expression during in vitro differentiation of mouse embryonic stem cells. Cytokines Mol Ther. 1995 Jun;1(2):139-43
    • Latest
      J:344312 Liu H, et al., Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development. iScience. 2024 Jan 19;27(1):108722
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory