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Lcp1 Gene Detail
Summary
  • Symbol
    Lcp1
  • Name
    lymphocyte cytosolic protein 1
  • Synonyms
    D14Ertd310e, L-fimbrin, L-plastin, Pls2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104808
    NCBI Gene: 18826
  • Alliance
  • Transcription Start Sites
    62 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:75368570-75468282 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 39.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3318 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104808
protein coding gene Chr14:75368541-75468282 (+)
129S1/SvImJ ENSMUSG00200010171
protein coding gene Chr14:63790028-63890766 (+)
A/J ENSMUSG00195003785
protein coding gene Chr14:64012230-64045006 (+)
AKR/J ENSMUSG00220007272
protein coding gene Chr14:63399754-63432543 (+)
BALB/cJ ENSMUSG00180019938
protein coding gene Chr14:63604276-63637048 (+)
C3H/HeJ ENSMUSG00175028826
protein coding gene Chr14:65420756-65453536 (+)
C57BL/6NJ ENSMUSG00215016894
protein coding gene Chr14:63599568-63632340 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019510
protein coding gene Chr14:66027447-66127702 (+)
CAST/EiJ ENSTCUG00005029384
protein coding gene Chr14:65183073-65283520 (+)
CBA/J ENSMUSG00210010042
protein coding gene Chr14:64035664-64068440 (+)
DBA/2J ENSMUSG00185022721
protein coding gene Chr14:69180232-69213008 (+)
FVB/NJ ENSMUSG00205022596
protein coding gene Chr14:63427815-63460584 (+)
JF1/MsJ ENSUMUG00000040505
protein coding gene Chr14:80276811-80377168 (+)
LP/J ENSMUSG00230014763
protein coding gene Chr14:81207102-81240832 (+)
NOD/ShiLtJ ENSMUSG00190010332
protein coding gene Chr14:63804631-63838373 (+)
NZO/HlLtJ ENSMUSG00225039317
protein coding gene Chr14:71457987-71558906 (+)
PWK/PhJ ENSLUMG00010010866
protein coding gene Chr14:63141823-63242089 (+)
SPRET/EiJ ENSMSPG00010024835
protein coding gene Chr14:66771424-66869609 (+)
WSB/EiJ ENSIUOG00005022240
protein coding gene Chr14:63181949-63214714 (+)



Homology
more
  • Human Ortholog
    LCP1, lymphocyte cytosolic protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LCP1, lymphocyte cytosolic protein 1
  • Synonyms
    CP64, HEL-S-37, LC64P, L-PLASTIN, PLS2
  • Links
    NCBI Gene ID: 3936
    UniProt: P13796

  • Chr Location
    13q14.13; chr13:46125920-46211871 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human LCP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to S. aureus infection, defective neutrophil killing of S. aureus, and impaired adhesion-dependent respiratory bursts in neutrophils.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18826 NCBI Gene Model | MGI Sequence Detail 99713 C57BL/6J ±  kb
    transcript NM_001424513 RefSeq | MGI Sequence Detail 4112 C57BL/6  
    polypeptide Q61233 UniProt | EBI | MGI Sequence Detail 627 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 35
      Primer pair 2
      Antibodies 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-28102, MGI:1261889, MGI:2145820
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 9
      Gene Ontology 11
      Phenotypes 25
    • Earliest
      J:289366 Ezzell RM, et al., Differential localization of villin and fimbrin during development of the mouse visceral endoderm and intestinal epithelium. Development. 1989 Jun;106(2):407-19
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    09/01/2026
    MGI 6.24
    The Jackson Laboratory