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Lamc1 Gene Detail
Summary
  • Symbol
    Lamc1
  • Name
    laminin, gamma 1
  • Synonyms
    Lamb2, laminin B2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99914
    NCBI Gene: 226519
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:153094668-153208532 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 65.30 cM
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3384 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99914
 protein coding gene Chr1:153094668-153208532 (-)
129S1/SvImJ ENSMUSG00200001904
 protein coding gene Chr1:150535068-150649509 (-)
A/J ENSMUSG00195013383
 protein coding gene Chr1:149913122-150026988 (-)
AKR/J ENSMUSG00220005502
 protein coding gene Chr1:149721319-149835787 (-)
BALB/cJ ENSMUSG00180030708
 protein coding gene Chr1:150142847-150256696 (-)
C3H/HeJ ENSMUSG00175002857
 protein coding gene Chr1:150179680-150293530 (-)
C57BL/6NJ ENSMUSG00215003337
 protein coding gene Chr1:150077768-150191649 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014707
 protein coding gene Chr1:143960579-144077462 (-)
CAST/EiJ ENSTCUG00005005732
 protein coding gene Chr1:148708219-148822827 (-)
CBA/J ENSMUSG00210030509
 protein coding gene Chr1:150083516-150197362 (-)
DBA/2J ENSMUSG00185043184
 protein coding gene Chr1:154340871-154454273 (-)
FVB/NJ ENSMUSG00205028312
 protein coding gene Chr1:149206072-149319417 (-)
JF1/MsJ ENSUMUG00000013804
 protein coding gene Chr1:153525089-153639399 (-)
LP/J ENSMUSG00230013423
 protein coding gene Chr1:153911322-154024938 (-)
NOD/ShiLtJ ENSMUSG00190011463
 protein coding gene Chr1:149897295-150010693 (-)
NZO/HlLtJ ENSMUSG00225005894
 protein coding gene Chr1:157595932-157710365 (-)
PWK/PhJ ENSLUMG00010027429
 protein coding gene Chr1:148873266-148986619 (-)
SPRET/EiJ ENSMSPG00010004980
 protein coding gene Chr1:152193041-152307735 (-)
WSB/EiJ ENSIUOG00005021874
 protein coding gene Chr1:149486500-149599837 (-)



Homology
more
  • Human Ortholog
    LAMC1, laminin subunit gamma 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAMC1, laminin subunit gamma 1
  • Synonyms
    LAMB2
  • Links
    NCBI Gene ID: 3915
    UniProt: P11047

  • Chr Location
    1q25.3; chr1:183023420-183145592 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    73 phenotypes from 9 alleles in 10 genetic backgrounds
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null homozygotes are lethal by E5.5, lack basement membrane and parietal yolk sac development, and migration of primitive endoderm cells from the inner cell mass. Homozygotes for a transposon-induced allele are lethal between E10.5-E12.5 and abnormal body size. Exon 2 deleted mice show muscle abnormalities, demylination, and paraparesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    75
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1312
  • Tissues
    404
  • cDNA Data
    233
  • Literature Summary
    120
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 226519 NCBI Gene Model | MGI Sequence Detail 113865 C57BL/6J ±  kb
    transcript NM_010683 RefSeq | MGI Sequence Detail 7622 Not Specified  
    polypeptide P02468 UniProt | EBI | MGI Sequence Detail 1607 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 247
      Genomic 1
      cDNA 233
      Primer pair 9
      Other 4
      Antibodies 19

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16712
    References
    more
    • Summaries
      All 248
      Developmental Gene Expression 120
      Gene Ontology 33
      Phenotypes 45
    • Earliest
      J:7643 Barlow DP, et al., Sequencing of laminin B chain cDNAs reveals C-terminal regions of coiled-coil alpha-helix. EMBO J. 1984 Oct;3(10):2355-62
    • Latest
      J:391720 Ruan J, et al., Loss of laminin-gamma1 in pericytes impairs microvascular function and cognition. Cell Rep. 2026 Aug 27;45(9):117904
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory