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Cdc25b Gene Detail
Summary
  • Symbol
    Cdc25b
  • Name
    cell division cycle 25B
  • Feature Type
    protein coding gene
  • IDs
    MGI:99701
    NCBI Gene: 12531
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:131028869-131040417 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.29 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99701
 protein coding gene Chr2:131028356-131040431 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026526
 protein coding gene Chr2:134699609-134713042 (+)
A/J MGP_AJ_G0026490
 protein coding gene Chr2:129233436-129244941 (+)
AKR/J MGP_AKRJ_G0026465
 protein coding gene Chr2:132966722-132978259 (+)
BALB/cJ MGP_BALBcJ_G0026502
 protein coding gene Chr2:129620023-129631561 (+)
C3H/HeJ MGP_C3HHeJ_G0026245
 protein coding gene Chr2:133400999-133412537 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026947
 protein coding gene Chr2:138836227-138847758 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024324
 protein coding gene Chr2:123978591-123990165 (+)
CAST/EiJ MGP_CASTEiJ_G0025706
 protein coding gene Chr2:133683721-133695322 (+)
CBA/J MGP_CBAJ_G0026225
 protein coding gene Chr2:144008250-144019792 (+)
DBA/2J MGP_DBA2J_G0026359
 protein coding gene Chr2:128623705-128635500 (+)
FVB/NJ MGP_FVBNJ_G0026323
 protein coding gene Chr2:127253379-127264915 (+)
LP/J MGP_LPJ_G0026464
 protein coding gene Chr2:134929084-134940605 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026343
 protein coding gene Chr2:147821191-147842683 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027002
 protein coding gene Chr2:132916364-132935571 (+)
PWK/PhJ MGP_PWKPhJ_G0025442
 protein coding gene Chr2:128193754-128205414 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025244
 protein coding gene Chr2:132073975-132087220 (+)
WSB/EiJ MGP_WSBEiJ_G0025780
 protein coding gene Chr2:133846116-133857694 (+)



Homology
more
  • Human Ortholog
    CDC25B, cell division cycle 25B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDC25B, cell division cycle 25B
  • Links
    NCBI Gene ID: 994
    neXtProt AC: NX_P30305
    UniProt: P30305

  • Chr Location
    20p13; chr20:3786772-3806121 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    4 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The resumption of meiosis during oocyte maturation is blocked in homozygous mutant female mice, resulting in female infertility. Male mice do not show an overt reproductive phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    34
  • cDNA Data
    60
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027330 Ensembl Gene Model | MGI Sequence Detail 11549 C57BL/6J ±  kb
    transcript ENSMUST00000028804 Ensembl | MGI Sequence Detail 3089 Not Applicable  
    polypeptide ENSMUSP00000028804 Ensembl | MGI Sequence Detail 576 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      Genomic 4
      cDNA 61
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16486, MGI:2139016
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 26
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:333724 Park EJ, et al., Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Nat Commun. 2023 Feb 25;14(1):1097
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory