About   Help   FAQ
Siglec1 Gene Detail
Summary
  • Symbol
    Siglec1
  • Name
    sialic acid binding Ig-like lectin 1, sialoadhesin
  • Synonyms
    CD169, Siglec-1, Sn
  • Feature Type
    protein coding gene
  • IDs
    MGI:99668
    NCBI Gene: 20612
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:130911140-130928685 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.26 cM, cytoband F-H1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99668
 protein coding gene Chr2:130911140-130928697 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026520
 protein coding gene Chr2:134572530-134594886 (-)
A/J MGP_AJ_G0026484
 protein coding gene Chr2:129116581-129134926 (-)
AKR/J MGP_AKRJ_G0026459
 protein coding gene Chr2:132852412-132869849 (-)
BALB/cJ MGP_BALBcJ_G0026496
 protein coding gene Chr2:129504109-129521514 (-)
C3H/HeJ MGP_C3HHeJ_G0026239
 protein coding gene Chr2:133278947-133297299 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026941
 protein coding gene Chr2:138720653-138739142 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024318
 protein coding gene Chr2:123855436-123876384 (-)
CAST/EiJ MGP_CASTEiJ_G0025700
 protein coding gene Chr2:133556775-133578690 (-)
CBA/J MGP_CBAJ_G0026219
 protein coding gene Chr2:143870428-143890737 (-)
DBA/2J MGP_DBA2J_G0026353
 protein coding gene Chr2:128511573-128528340 (-)
FVB/NJ MGP_FVBNJ_G0026317
 protein coding gene Chr2:127138049-127158767 (-)
LP/J MGP_LPJ_G0026458
 protein coding gene Chr2:134814754-134832185 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026337
 protein coding gene Chr2:147690176-147707605 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026996
 protein coding gene Chr2:132803541-132821748 (-)
PWK/PhJ MGP_PWKPhJ_G0025436
 protein coding gene Chr2:128073028-128091361 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025238
 protein coding gene Chr2:131957821-131975071 (-)
WSB/EiJ MGP_WSBEiJ_G0025774
 protein coding gene Chr2:133728142-133745561 (-)



Homology
more
  • Human Ortholog
    SIGLEC1, sialic acid binding Ig like lectin 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIGLEC1, sialic acid binding Ig like lectin 1
  • Synonyms
    CD169, SIGLEC-1, SN
  • Links
    NCBI Gene ID: 6614
    neXtProt AC: NX_Q9BZZ2
    UniProt: Q9BZZ2

  • Chr Location
    20p13; chr20:3686970-3712600 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    101 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display subtle changes in B- and T-cell populations and decreased IgM levels. Mice homozygous for a knock-out or knock-in allele exhibit impaired phagocytosis of sialylated C. jejuni.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    9
  • cDNA Data
    29
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027322 Ensembl Gene Model | MGI Sequence Detail 17546 C57BL/6J ±  kb
    transcript ENSMUST00000028794 Ensembl | MGI Sequence Detail 6387 Not Applicable  
    polypeptide ENSMUSP00000028794 Ensembl | MGI Sequence Detail 1701 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 10
      cDNA 29
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16453
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 101
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:341108 Chen D, et al., CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma. Immunity. 2023 Sep 12;56(9):2086-2104.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory