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Pde4b Gene Detail
Summary
  • Symbol
    Pde4b
  • Name
    phosphodiesterase 4B, cAMP specific
  • Synonyms
    Dpde4, dunce
  • Feature Type
    protein coding gene
  • IDs
    MGI:99557
    NCBI Gene: 18578
  • Alliance
    genome feature page
  • Transcription Start Sites
    34 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:101944740-102464456 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 46.99 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14596 from dbSNP Build 142
  • Strain Annotations
    29
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99557
 protein coding gene Chr4:101944529-102464459 (+)
129S1/SvImJ ENSMUSG00200027825
 protein coding gene Chr4:97447099-97482864 (+)
129S1/SvImJ ENSMUSGG00200054610
 protein coding gene Chr4:97061464-97432924 (+)
A/J ENSMUSG00195007588
 protein coding gene Chr4:98006165-98041946 (+)
A/J ENSMUSGG00195055246
 protein coding gene Chr4:97607576-97991998 (+)
AKR/J ENSMUSGG00220054783
 protein coding gene Chr4:97011507-97415712 (+)
AKR/J ENSMUSG00220005965
 protein coding gene Chr4:97429909-97465609 (+)
BALB/cJ ENSMUSG00180032179
 protein coding gene Chr4:96875621-96911398 (+)
C3H/HeJ ENSMUSG00175013648
 protein coding gene Chr4:97875045-97910823 (+)
C3H/HeJ ENSMUSGG00175054874
 protein coding gene Chr4:97476470-97860878 (+)
C57BL/6NJ ENSMUSG00215015017
 protein coding gene Chr4:97807068-97842842 (+)
C57BL/6NJ ENSMUSGG00215055591
 protein coding gene Chr4:97421553-97792897 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026213
 protein coding gene Chr4:94258266-94777042 (+)
CAST/EiJ ENSTCUG00005006852
 protein coding gene Chr4:97053402-97089445 (+)
CBA/J ENSMUSGG00210054617
 protein coding gene Chr4:97100090-97484496 (+)
CBA/J ENSMUSG00210026640
 protein coding gene Chr4:97498663-97534438 (+)
DBA/2J ENSMUSG00185021401
 protein coding gene Chr4:98204545-98240313 (+)
DBA/2J ENSMUSGG00185057824
 protein coding gene Chr4:97818885-98190374 (+)
FVB/NJ ENSMUSG00205009863
 protein coding gene Chr4:96398769-96434534 (+)
FVB/NJ ENSMUSGG00205054307
 protein coding gene Chr4:96013117-96384597 (+)
JF1/MsJ ENSUMUG00000024242
 protein coding gene Chr4:98279270-98315302 (+)
LP/J ENSMUSGG00230055689
 protein coding gene Chr4:101123754-101495194 (+)
LP/J ENSMUSG00230019200
 protein coding gene Chr4:101509362-101545126 (+)
NOD/ShiLtJ ENSMUSGG00190054774
 protein coding gene Chr4:96484937-96856375 (+)
NOD/ShiLtJ ENSMUSG00190028207
 protein coding gene Chr4:96870543-96906295 (+)
NZO/HlLtJ ENSMUSG00225031796
 protein coding gene Chr4:106621342-106657118 (+)
NZO/HlLtJ ENSMUSGG00225055447
 protein coding gene Chr4:106221873-106607162 (+)
PWK/PhJ ENSLUMG00010017452
 protein coding gene Chr4:96002810-96038734 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005002602
 protein coding gene Chr4:97111404-97147095 (+)



Homology
more
  • Human Ortholog
    PDE4B, phosphodiesterase 4B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE4B, phosphodiesterase 4B
  • Synonyms
    DPDE4, PDEIVB
  • Links
    NCBI Gene ID: 5142
    UniProt: Q07343

  • Chr Location
    1p31.3; chr1:65792510-66374579 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PDE4B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene produce significantly less TNF-alpha in response to lipopolysaccharide stimulation. One mutation resulted in brain and spinal cord vacuoles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    111
  • cDNA Data
    22
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028525 Ensembl Gene Model | MGI Sequence Detail 519717 C57BL/6J ±  kb
    transcript ENSMUST00000106911 Ensembl | MGI Sequence Detail 3020 Not Applicable  
    polypeptide ENSMUSP00000102524 Ensembl | MGI Sequence Detail 736 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      21 Sequences
    • EC
      3.1.4.-, 3.1.4.53
    • InterPro Domains
      IPR023088 3'5'-cyclic nucleotide phosphodiesterase
      IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
      IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
      IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
      IPR003607 HD/PDEase domain
      IPR040844 Phosphodiesterase 4 upstream conserved regions (UCR)
    • GlyGen
      B1AWC9 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 16
      cDNA 24
      Primer pair 4
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16335, MGI:2140715
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 8
      Gene Ontology 16
      Phenotypes 42
    • Earliest
      J:18405 Milatovich A, et al., Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. Somat Cell Mol Genet. 1994 Mar;20(2):75-86
    • Latest
      J:380715 Fiedler E, et al., The cAMP-phosphodiesterase PDE4B2 controls peroxisome proliferator-activated receptor gamma expression and the initiation of adipogenesis in 3T3-L1 cells. Am J Physiol Endocrinol Metab. 2025 Dec 1;329(6):E874-E887
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory