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Ephx2 Gene Detail
Summary
  • Symbol
    Ephx2
  • Name
    epoxide hydrolase 2, cytoplasmic
  • Synonyms
    Eph2, sEH, sEP
  • Feature Type
    protein coding gene
  • IDs
    MGI:99500
    NCBI Gene: 13850
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:66321823-66361949 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.36 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1060 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99500
 protein coding gene Chr14:66321821-66361971 (-)
129S1/SvImJ ENSMUSG00200028952
 protein coding gene Chr14:54922344-54962469 (-)
A/J ENSMUSG00195012800
 protein coding gene Chr14:55099643-55139799 (-)
AKR/J ENSMUSG00220026660
 protein coding gene Chr14:54440142-54480316 (-)
BALB/cJ ENSMUSG00180033701
 protein coding gene Chr14:54715851-54756015 (-)
C3H/HeJ ENSMUSG00175035024
 protein coding gene Chr14:56458760-56498892 (-)
C57BL/6NJ ENSMUSG00215012356
 protein coding gene Chr14:54654800-54694935 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019435
 protein coding gene Chr14:57238734-57280526 (-)
CAST/EiJ ENSTCUG00005034493
 protein coding gene Chr14:56357711-56400938 (-)
CBA/J ENSMUSG00210036332
 protein coding gene Chr14:55086984-55127155 (-)
DBA/2J ENSMUSG00185031731
 protein coding gene Chr14:60256588-60296713 (-)
FVB/NJ ENSMUSG00205027945
 protein coding gene Chr14:54602477-54642649 (-)
JF1/MsJ ENSUMUG00000033911
 protein coding gene Chr14:71428475-71472530 (-)
LP/J ENSMUSG00230036059
 protein coding gene Chr14:72285866-72325990 (-)
NOD/ShiLtJ ENSMUSG00190036741
 protein coding gene Chr14:54881696-54921869 (-)
NZO/HlLtJ ENSMUSG00225038519
 protein coding gene Chr14:62614578-62654741 (-)
PWK/PhJ ENSLUMG00010033078
 protein coding gene Chr14:54319054-54363104 (-)
SPRET/EiJ ENSMSPG00010028690
 protein coding gene Chr14:57809567-57850946 (-)
WSB/EiJ ENSIUOG00005038897
 protein coding gene Chr14:54318283-54358429 (-)



Homology
more
  • Human Ortholog
    EPHX2, epoxide hydrolase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPHX2, epoxide hydrolase 2
  • Synonyms
    ABHD20, CEH, SEH
  • Links
    NCBI Gene ID: 2053
    UniProt: P34913

  • Chr Location
    8p21.2-p21.1; chr8:27490775-27548992 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human EPHX2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 4 genetic backgrounds
    121 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males homozygous for a targeted null mutation display a significant reduction in blood pressure both in the absence and presence of dietary salt loading. Both sexes exhibit altered arachidonic acid metabolism and reduced renal formation of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    69
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    96
  • cDNA Data
    134
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022040 Ensembl Gene Model | MGI Sequence Detail 40127 C57BL/6J ±  kb
transcript ENSMUST00000070515 Ensembl | MGI Sequence Detail 2035 Not Applicable  
polypeptide ENSMUSP00000069209 Ensembl | MGI Sequence Detail 554 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 135
    cDNA 134
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16276, MGI:2145794
References
more
  • Summaries
    All 189
    Developmental Gene Expression 5
    Gene Ontology 13
    Phenotypes 121
  • Earliest
    J:7687 Simmons DL, et al., Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes. J Biol Chem. 1985 Jan 10;260(1):515-21
  • Latest
    J:358085 Li X, et al., A regulatory loop involving the cytochrome P450-soluble epoxide hydrolase axis and TGF-beta signaling. iScience. 2024 Oct 18;27(10):110938
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory