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Rpl22 Gene Detail
Summary
  • Symbol
    Rpl22
  • Name
    ribosomal protein L22
  • Synonyms
    2700038K18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:99262
    NCBI Gene: 19934
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:152410199-152418528 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 83.03 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99262
 protein coding gene Chr4:152408893-152418539 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029180
 protein coding gene Chr4:156438480-156447394 (+)
A/J MGP_AJ_G0029145
 protein coding gene Chr4:149885048-149893497 (+)
AKR/J MGP_AKRJ_G0029093
 protein coding gene Chr4:153954572-153962901 (+)
BALB/cJ MGP_BALBcJ_G0029161
 protein coding gene Chr4:150351687-150360016 (+)
C3H/HeJ MGP_C3HHeJ_G0028882
 protein coding gene Chr4:154521666-154531537 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029610
 protein coding gene Chr4:162051097-162059426 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026856
 protein coding gene Chr4:142224498-142233194 (+)
CAST/EiJ MGP_CASTEiJ_G0028295
 protein coding gene Chr4:151873586-151882002 (+)
CBA/J MGP_CBAJ_G0028844
 protein coding gene Chr4:166883961-166892290 (+)
DBA/2J MGP_DBA2J_G0028993
 protein coding gene Chr4:149936815-149945144 (+)
FVB/NJ MGP_FVBNJ_G0028957
 protein coding gene Chr4:149099015-149107344 (+)
LP/J MGP_LPJ_G0029083
 protein coding gene Chr4:156365967-156374296 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028984
 protein coding gene Chr4:169893287-169902252 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029642
 protein coding gene Chr4:154493886-154502215 (+)
PWK/PhJ MGP_PWKPhJ_G0028015
 protein coding gene Chr4:146004546-146012960 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027849
 protein coding gene Chr4:148780880-148790687 (+)
WSB/EiJ MGP_WSBEiJ_G0028375
 protein coding gene Chr4:154681720-154691930 (+)



Homology
more
  • Human Ortholog
    RPL22, ribosomal protein L22
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPL22, ribosomal protein L22
  • Synonyms
    EAP, eL22, HBP15, HBP15/L22, L22
  • Links
    NCBI Gene ID: 6146
    neXtProt AC: NX_P35268
    UniProt: P35268

  • Chr Location
    1p36.31; chr1:6185020-6209389 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    218 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit arrested alpha beta lineage T cell differentiation at the beta selection stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    17
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028936 Ensembl Gene Model | MGI Sequence Detail 8330 C57BL/6J ±  kb
    transcript ENSMUST00000139685 Ensembl | MGI Sequence Detail 2051 Not Applicable  
    polypeptide ENSMUSP00000118787 Ensembl | MGI Sequence Detail 128 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16021, MGI:1914433
    References
    more
    • Summaries
      All 250
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 218
    • Earliest
      J:17186 Fujita Y, et al., A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22. Biochem Biophys Res Commun. 1994 Mar 15;199(2):706-13
    • Latest
      J:344725 Castell L, et al., Dopamine D2 receptors in WFS1-neurons regulate food-seeking and avoidance behaviors. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Feb 8;129:110883
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory