About   Help   FAQ
Rpl22 Gene Detail
Summary
  • Symbol
    Rpl22
  • Name
    ribosomal protein L22
  • Synonyms
    2700038K18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:99262
    NCBI Gene: 19934
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:152410199-152418528 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 83.03 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    335 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99262
 protein coding gene Chr4:152408893-152418539 (+)
129S1/SvImJ ENSMUSG00200018468
 protein coding gene Chr4:143476515-143485598 (+)
129S1/SvImJ ENSMUSG00200038356
 protein coding gene Chr7:11751174-11751638 (-)
A/J ENSMUSG00195016057
 protein coding gene Chr4:145111914-145121501 (+)
AKR/J ENSMUSG00220025385
 protein coding gene Chr4:144698434-144708019 (+)
BALB/cJ ENSMUSG00180002306
 protein coding gene Chr4:142794105-142803691 (+)
C3H/HeJ ENSMUSG00175016743
 protein coding gene Chr4:146079484-146088565 (+)
C3H/HeJ ENSMUSG00175048475
 protein coding gene Chr7:12633752-12634216 (-)
C57BL/6NJ ENSMUSG00215006661
 protein coding gene Chr4:144922564-144932150 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026856
 protein coding gene Chr4:142224498-142233194 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210052350
 protein coding gene Chr7:11860487-11860951 (-)
CBA/J ENSMUSG00210005610
 protein coding gene Chr4:144731131-144740224 (+)
DBA/2J ENSMUSG00185015339
 protein coding gene Chr4:148295560-148305145 (+)
FVB/NJ ENSMUSG00205019463
 protein coding gene Chr4:143192150-143201736 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230041882
 protein coding gene Chr7:19592984-19593448 (-)
LP/J ENSMUSG00230017895
 protein coding gene Chr4:155029205-155038298 (+)
NOD/ShiLtJ ENSMUSG00190003339
 protein coding gene Chr4:144394792-144404377 (+)
NZO/HlLtJ ENSMUSG00225023056
 protein coding gene Chr4:159022158-159031743 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RPL22, ribosomal protein L22
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPL22, ribosomal protein L22
  • Synonyms
    EAP, eL22, HBP15, HBP15/L22, L22
  • Links
    NCBI Gene ID: 6146
    UniProt: P35268

  • Chr Location
    1p36.31; chr1:6185020-6209389 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    363 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit arrested alpha beta lineage T cell differentiation at the beta selection stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    1
  • cDNA Data
    17
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028936 Ensembl Gene Model | MGI Sequence Detail 8330 C57BL/6J ±  kb
    transcript ENSMUST00000103191 Ensembl | MGI Sequence Detail 474 Not Applicable  
    polypeptide ENSMUSP00000099480 Ensembl | MGI Sequence Detail 128 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16021, MGI:1914433
    References
    more
    • Summaries
      All 402
      Developmental Gene Expression 3
      Gene Ontology 13
      Phenotypes 363
    • Earliest
      J:17186 Fujita Y, et al., A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22. Biochem Biophys Res Commun. 1994 Mar 15;199(2):706-13
    • Latest
      J:390539 Chaudhuri S, et al., Glial Connexin-43 Is a Pathogenic Mechanism Promoting Gut Inflammation in Postoperative Ileus Induced by Gut Surgical Manipulation With Potential Relevance to Humans. Cell Mol Gastroenterol Hepatol. 2026;20(7):101755
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory