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Yaa Cytogenetic Marker Detail
Summary
  • Symbol
    Yaa
  • Name
    accelerated autoimmunity and lymphoproliferation transposition
  • Synonyms
    Tp(X;Y)1Ekw
  • Feature Type
    chromosomal translocation
  • IDs
    MGI:99140
    NCBI Gene: 107944
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome Y, Syntenic
  • Mapping Data
    1 experiment
Human Diseases
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  • Diseases
    1 with Yaa mouse models

Human Disease Mouse Models
      
IDs
View 5 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 1 allele in 10 genetic backgrounds
    45 phenotypes from multigenic genotypes
    2 images
    99 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant males have accelerated autoimmunity, lymphoproliferation, splenomegaly, hemolytic anemia, hypergammaglobulinemia and glomerulonephritis. The syndrome is strain-dependent, requiring presence of certain autosomal allelic combinations.
Sequences &
Gene Models
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Other
Accession IDs
less
MGD-MRK-15837
References
more
  • Summaries
    All 117
    Diseases 7
    Phenotypes 99
  • Earliest
    J:6235 Murphy ED, et al., A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum. 1979 Nov;22(11):1188-94
  • Latest
    J:345002 Ni H, et al., Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice. Nat Commun. 2024 Jan 2;15(1):1

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory