About   Help   FAQ
Wnt4 Gene Detail
Summary
  • Symbol
    Wnt4
  • Name
    wingless-type MMTV integration site family, member 4
  • Synonyms
    Wnt-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:98957
    NCBI Gene: 22417
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:137004946-137026812 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 69.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    542 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98957
 protein coding gene Chr4:137004800-137027037 (+)
129S1/SvImJ ENSMUSG00200020507
 protein coding gene Chr4:130422800-130445029 (+)
A/J ENSMUSG00195043187
 protein coding gene Chr4:131779102-131801400 (+)
AKR/J ENSMUSG00220046800
 protein coding gene Chr4:130770818-130793120 (+)
BALB/cJ ENSMUSG00180045945
 protein coding gene Chr4:129413017-129435301 (+)
C3H/HeJ ENSMUSG00175045440
 protein coding gene Chr4:130433455-130455813 (+)
C57BL/6NJ ENSMUSG00215049725
 protein coding gene Chr4:131945734-131967991 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026673
 protein coding gene Chr4:126963270-126985458 (+)
CAST/EiJ ENSTCUG00005045926
 protein coding gene Chr4:131356870-131379080 (+)
CBA/J ENSMUSG00210053882
 protein coding gene Chr4:130057360-130079709 (+)
DBA/2J ENSMUSG00185048033
 protein coding gene Chr4:131586320-131608598 (+)
FVB/NJ ENSMUSG00205041745
 protein coding gene Chr4:129826846-129849133 (+)
JF1/MsJ ENSUMUG00000042155
 protein coding gene Chr4:132280027-132302292 (+)
LP/J ENSMUSG00230032706
 protein coding gene Chr4:135360927-135383144 (+)
NOD/ShiLtJ ENSMUSG00190046127
 protein coding gene Chr4:129819486-129841721 (+)
NZO/HlLtJ ENSMUSG00225026611
 protein coding gene Chr4:141316075-141338310 (+)
PWK/PhJ ENSLUMG00010044390
 protein coding gene Chr4:129268683-129290983 (+)
SPRET/EiJ ENSMSPG00010040905
 protein coding gene Chr4:131340544-131362795 (+)
WSB/EiJ ENSIUOG00005037224
 protein coding gene Chr4:129713453-129735725 (+)



Homology
more
  • Human Ortholog
    WNT4, Wnt family member 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNT4, Wnt family member 4
  • Synonyms
    SERKAL, WNT-4
  • Links
    NCBI Gene ID: 54361
    UniProt: P56705

  • Chr Location
    1p36.12; chr1:22117313-22143969 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human WNT4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    76 phenotypes from 12 alleles in 12 genetic backgrounds
    23 phenotypes from multigenic genotypes
    7 images
    134 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit impaired development of the kidney, pituitary gland, and female reproductive system. Mutants die within 24 hours of birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    151
  • GO References
    44
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1997
  • Tissues
    764
  • cDNA Data
    59
  • Literature Summary
    387
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22417 NCBI Gene Model | MGI Sequence Detail 21867 C57BL/6J ±  kb
    transcript NM_009523 RefSeq | MGI Sequence Detail 3823 C57BL/6  
    polypeptide P22724 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 145
      Genomic 1
      cDNA 65
      Primer pair 49
      Other 30
      Antibodies 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15442, MGD-MRK-15452
    References
    more
    • Summaries
      All 585
      Developmental Gene Expression 387
      Gene Ontology 44
      Phenotypes 134
    • Earliest
      J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
    • Latest
      J:391359 Palhazi B, et al., The absence of Trim28 in nephron progenitors results in impaired kidney development and function. Development. 2026 Aug 1;153(15):dev205188
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory