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Wnt3a Gene Detail
Summary
  • Symbol
    Wnt3a
  • Name
    wingless-type MMTV integration site family, member 3A
  • Synonyms
    Wnt-3a
  • Feature Type
    protein coding gene
  • IDs
    MGI:98956
    NCBI Gene: 22416
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:59138859-59181578 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.17 cM
  • Mapping Data
    27 experiments
Strain
Comparison
more
  • SNPs within 2kb
    374 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98956
protein coding gene Chr11:59138859-59181579 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018394
protein coding gene Chr11:59069740-59114747 (-)
A/J MGP_AJ_G0018363
protein coding gene Chr11:56811512-56854816 (-)
AKR/J MGP_AKRJ_G0018333
protein coding gene Chr11:58712730-58755909 (-)
BALB/cJ MGP_BALBcJ_G0018334
protein coding gene Chr11:57167239-57210129 (-)
C3H/HeJ MGP_C3HHeJ_G0018147
protein coding gene Chr11:58590106-58632241 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018786
protein coding gene Chr11:60945091-60988054 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016432
protein coding gene Chr11:54062807-54105615 (-)
CAST/EiJ MGP_CASTEiJ_G0017704
protein coding gene Chr11:58719603-58764482 (-)
CBA/J MGP_CBAJ_G0018121
protein coding gene Chr11:63596368-63652895 (-)
DBA/2J MGP_DBA2J_G0018230
protein coding gene Chr11:56483328-56525862 (-)
FVB/NJ MGP_FVBNJ_G0018221
protein coding gene Chr11:56127756-56177053 (-)
LP/J MGP_LPJ_G0018303
protein coding gene Chr11:59667614-59716991 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018245
protein coding gene Chr11:64742399-64789741 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018827
protein coding gene Chr11:58736538-58780779 (-)
PWK/PhJ MGP_PWKPhJ_G0017475
protein coding gene Chr11:57066074-57110685 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017267
protein coding gene Chr11:58528131-58575332 (-)
WSB/EiJ MGP_WSBEiJ_G0017755
protein coding gene Chr11:58419769-58466277 (-)



Homology
more
  • Human Ortholog
    WNT3A, Wnt family member 3A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNT3A, Wnt family member 3A
  • Links
    NCBI Gene ID: 89780
    neXtProt AC: NX_P56704
    UniProt: P56704

  • Chr Location
    1q42.13; chr1:228006998-228061271 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 5 alleles in 10 genetic backgrounds
    29 phenotypes from multigenic genotypes
    2 images
    95 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die at embryonic day 10.5-12.5 with failed development of caudal somites, notochord and structures rostral to hindlimbs. Homozygotes for a hypomorphic allele have vertebral defects and a short tail due to loss of caudal vertebrae.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009900 Ensembl Gene Model | MGI Sequence Detail 42720 C57BL/6J ±  kb
    transcript ENSMUST00000010044 Ensembl | MGI Sequence Detail 2761 Not Applicable  
    polypeptide ENSMUSP00000010044 Ensembl | MGI Sequence Detail 352 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 3
      cDNA 24
      Primer pair 23
      Other 34

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15417, MGD-MRK-15441, MGD-MRK-15451
    References
    more
    • Summaries
      All 605
      Developmental Gene Expression 327
      Gene Ontology 88
      Phenotypes 95
    • Earliest
      J:13062 HESTON WE, The 'vestigial tail' mouse; a new recessive mutation. J Hered. 1951 Mar-Apr;42(2):71-4
    • Latest
      J:341689 Zhang B, et al., KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors. Nat Commun. 2023 Oct 14;14(1):6489

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory