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Tgm3 Gene Detail
Summary
  • Symbol
    Tgm3
  • Name
    transglutaminase 3, E polypeptide
  • Synonyms
    TG E, we
  • Feature Type
    protein coding gene
  • IDs
    MGI:98732
    NCBI Gene: 21818
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:129854269-129892319 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.19 cM
  • Mapping Data
    35 experiments
Strain
Comparison
more
  • SNPs within 2kb
    304 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98732
 protein coding gene Chr2:129829700-129892319 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026493
 protein coding gene Chr2:133429056-133471557 (+)
A/J MGP_AJ_G0026457
 protein coding gene Chr2:128049452-128088124 (+)
AKR/J MGP_AKRJ_G0026432
 protein coding gene Chr2:131708223-131747835 (+)
BALB/cJ MGP_BALBcJ_G0026469
 protein coding gene Chr2:128395684-128433973 (+)
C3H/HeJ MGP_C3HHeJ_G0026212
 protein coding gene Chr2:132172555-132210559 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026914
 protein coding gene Chr2:137579521-137626156 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024291
 protein coding gene Chr2:122798219-122836954 (+)
CAST/EiJ MGP_CASTEiJ_G0025673
 protein coding gene Chr2:132415223-132454521 (+)
CBA/J MGP_CBAJ_G0026192
 protein coding gene Chr2:142676634-142717316 (+)
DBA/2J MGP_DBA2J_G0026326
 protein coding gene Chr2:127441830-127480077 (+)
FVB/NJ MGP_FVBNJ_G0026290
 protein coding gene Chr2:126059987-126098476 (+)
LP/J MGP_LPJ_G0026431
 protein coding gene Chr2:133692893-133734336 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026310
 protein coding gene Chr2:146538957-146579421 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026969
 protein coding gene Chr2:131688775-131728876 (+)
PWK/PhJ MGP_PWKPhJ_G0025409
 protein coding gene Chr2:126988843-127027580 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025211
 protein coding gene Chr2:130807808-130846902 (+)
WSB/EiJ MGP_WSBEiJ_G0025747
 protein coding gene Chr2:132617077-132660224 (+)



Homology
more
  • Human Ortholog
    TGM3, transglutaminase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGM3, transglutaminase 3
  • Synonyms
    TGE, UHS2
  • Links
    NCBI Gene ID: 7053
    neXtProt AC: NX_Q08188
    UniProt: Q08188

  • Chr Location
    20p13; chr20:2296001-2341079 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 7 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    4 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU or null mutation exhibit rough-looking, curly hair. Null mutants display delayed skin barrier formation, loss of vibrissae, and brittle hairs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1115
  • Tissues
    197
  • cDNA Data
    22
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027401 Ensembl Gene Model | MGI Sequence Detail 38051 C57BL/6J ±  kb
    transcript ENSMUST00000110299 Ensembl | MGI Sequence Detail 4135 Not Applicable  
    polypeptide ENSMUSP00000105928 Ensembl | MGI Sequence Detail 693 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 22
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15074, MGD-MRK-15431, MGI:2139112, MGI:98947
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 12
      Gene Ontology 8
      Phenotypes 29
    • Earliest
      J:208 Hertwig P, Neue Mutationen und Koppelungsgruppen bei der Hausmaus. Z Indukt Abstamm Vererbungsl. 1942;80(1):220-246
    • Latest
      J:335426 Butera A, et al., ZFP750 affects the cutaneous barrier through regulating lipid metabolism. Sci Adv. 2023 Apr 28;9(17):eadg5423
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory