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Vcam1 Gene Detail
Summary
  • Symbol
    Vcam1
  • Name
    vascular cell adhesion molecule 1
  • Synonyms
    CD106, Vcam-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98926
    NCBI Gene: 22329
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:115903669-115923337 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 50.17 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    607 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98926
 protein coding gene Chr3:115903598-115923337 (-)
129S1/SvImJ ENSMUSG00200025037
 protein coding gene Chr3:112561075-112580795 (-)
A/J ENSMUSG00195014511
 protein coding gene Chr3:112805794-112825490 (-)
AKR/J ENSMUSG00220025435
 protein coding gene Chr3:111213117-111232809 (-)
BALB/cJ ENSMUSG00180026492
 protein coding gene Chr3:112750519-112770222 (-)
C3H/HeJ ENSMUSG00175024079
 protein coding gene Chr3:112291048-112310747 (-)
C57BL/6NJ ENSMUSG00215005159
 protein coding gene Chr3:113028801-113048548 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025562
 protein coding gene Chr3:109817917-109837522 (-)
CAST/EiJ ENSTCUG00005031643
 protein coding gene Chr3:113287149-113306937 (-)
CBA/J ENSMUSG00210002680
 protein coding gene Chr3:112899818-112919517 (-)
DBA/2J ENSMUSG00185007057
 protein coding gene Chr3:113489852-113509548 (-)
FVB/NJ ENSMUSG00205025586
 protein coding gene Chr3:111838761-111858469 (-)
JF1/MsJ ENSUMUG00000001057
 protein coding gene Chr3:112383860-112403522 (-)
LP/J ENSMUSG00230011457
 protein coding gene Chr3:115421959-115441676 (-)
NOD/ShiLtJ ENSMUSG00190025625
 protein coding gene Chr3:113841649-113861374 (-)
NZO/HlLtJ ENSMUSG00225002996
 protein coding gene Chr3:117912199-117931894 (-)
PWK/PhJ ENSLUMG00010023446
 protein coding gene Chr3:112271057-112290790 (-)
SPRET/EiJ ENSMSPG00010027249
 protein coding gene Chr3:112899800-112919298 (-)
WSB/EiJ ENSIUOG00005006930
 protein coding gene Chr3:113047737-113067470 (-)



Homology
more
  • Human Ortholog
    VCAM1, vascular cell adhesion molecule 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VCAM1, vascular cell adhesion molecule 1
  • Synonyms
    CD106, INCAM-100
  • Links
    NCBI Gene ID: 7412
    UniProt: P19320

  • Chr Location
    1p21.2; chr1:100719684-100739045 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human VCAM1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 7 alleles in 9 genetic backgrounds
    8 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most homozygous null mutants die by embryonic day 12.5 due to defective placenta and failure of chorion/allantois fusion, and heart developmental anomalies. Survivors are generally normal, but have high numbers of circulating blood mononuclear leukocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    864
  • Tissues
    162
  • cDNA Data
    29
  • Literature Summary
    130
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22329 NCBI Gene Model | MGI Sequence Detail 19669 C57BL/6J ±  kb
    transcript NM_011693 RefSeq | MGI Sequence Detail 3398 Not Specified  
    polypeptide P29533 UniProt | EBI | MGI Sequence Detail 739 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000001970 vascular cell adhesion protein 1
      (term hierarchy)
    • InterPro Domains
      IPR008424 Immunoglobulin C2-set
      IPR003599 Immunoglobulin domain subtype
      IPR013098 Immunoglobulin I-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003598 Immunoglobulin subtype 2
      IPR047012 Intercellular adhesion molecule/vascular cell adhesion molecule
      IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
      IPR003989 Vascular cell adhesion molecule-1
    • GlyGen
      P29533 5 sites, 10 N-linked glycans (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 13
      cDNA 30
      Primer pair 10
      Other 2
      Antibodies 19

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-15384, MGD-MRK-15385
    References
    more
    • Summaries
      All 303
      Developmental Gene Expression 130
      Diseases 1
      Gene Ontology 17
      Phenotypes 43
    • Earliest
      J:18518 Osborn L, et al., Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell. 1989 Dec 22;59(6):1203-11
    • Latest
      J:390609 Baldwin HS, et al., Endocardial TIE2 orchestrates cardiac trabeculation via sequestering FOXO1 within the cytoplasm and stimulating versican cleavage. Development. 2026 Jul 15;153(14):dev205674
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory