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Upk3a Gene Detail
Summary
  • Symbol
    Upk3a
  • Name
    uroplakin 3A
  • Synonyms
    1110017C07Rik, Upk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98914
    NCBI Gene: 22270
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:84901342-84906748 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 40.25 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    98 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98914
 protein coding gene Chr15:84901342-84906761 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022186
 protein coding gene Chr15:85836442-85841861 (+)
A/J MGP_AJ_G0022145
 protein coding gene Chr15:82669470-82674889 (+)
AKR/J MGP_AKRJ_G0022120
 protein coding gene Chr15:85112487-85117909 (+)
BALB/cJ MGP_BALBcJ_G0022151
 protein coding gene Chr15:82792984-82798403 (+)
C3H/HeJ MGP_C3HHeJ_G0021921
 protein coding gene Chr15:85042051-85047470 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022596
 protein coding gene Chr15:89097986-89103405 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020121
 protein coding gene Chr15:79016097-79021592 (+)
CAST/EiJ MGP_CASTEiJ_G0021443
 protein coding gene Chr15:85820910-85842973 (+)
CBA/J MGP_CBAJ_G0021888
 protein coding gene Chr15:91994267-91999686 (+)
DBA/2J MGP_DBA2J_G0022015
 protein coding gene Chr15:82139646-82144874 (+)
FVB/NJ MGP_FVBNJ_G0021994
 protein coding gene Chr15:81211324-81216743 (+)
LP/J MGP_LPJ_G0022086
 protein coding gene Chr15:85999537-86004956 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022014
 protein coding gene Chr15:96773472-96778894 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022611
 protein coding gene Chr15:85105040-85110459 (+)
PWK/PhJ MGP_PWKPhJ_G0021184
 protein coding gene Chr15:82146968-82152202 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021018
 protein coding gene Chr15:84813153-84818580 (+)
WSB/EiJ MGP_WSBEiJ_G0021492
 protein coding gene Chr15:85599667-85604895 (+)



Homology
more
  • Human Ortholog
    UPK3A, uroplakin 3A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UPK3A, uroplakin 3A
  • Synonyms
    UP3A, UPIII, UPIIIA, UPK3
  • Links
    NCBI Gene ID: 7380
    neXtProt AC: NX_O75631
    UniProt: O75631

  • Chr Location
    22q13.31; chr22:45284949-45295874 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Upk3a mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    5 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit urogenital defects including abnormal urothelium, vesicoureteral reflux, and hydronephrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1063
  • Tissues
    230
  • cDNA Data
    13
  • Literature Summary
    42
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022435 Ensembl Gene Model | MGI Sequence Detail 5407 C57BL/6J ±  kb
    transcript ENSMUST00000023070 Ensembl | MGI Sequence Detail 1093 Not Applicable  
    polypeptide ENSMUSP00000023070 Ensembl | MGI Sequence Detail 287 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 14
      Primer pair 5
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15369, MGI:1915869
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 42
      Diseases 2
      Gene Ontology 8
      Phenotypes 29
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:330441 Ortega MA, et al., Exocyst inactivation in urothelial cells disrupts autophagy and activates non-canonical NF-kappaB signaling. Dis Model Mech. 2022 Oct 1;15(10):dmm049785
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory