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Thy1 Gene Detail
Summary
  • Symbol
    Thy1
  • Name
    thymus cell antigen 1, theta
  • Synonyms
    CD90, T25, theta, Thy-1, Thy1.1, Thy 1.2, Thy-1.2, Thy1.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98747
    NCBI Gene: 21838
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:43954681-43959876 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.52 cM
  • Mapping Data
    55 experiments
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98747
protein coding gene Chr9:43954681-43959876 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034688
protein coding gene Chr9:42488490-42493710 (+)
A/J MGP_AJ_G0034668
protein coding gene Chr9:41327259-41332429 (+)
AKR/J MGP_AKRJ_G0034594
protein coding gene Chr9:42180842-42188120 (+)
BALB/cJ MGP_BALBcJ_G0034659
protein coding gene Chr9:41067582-41073086 (+)
C3H/HeJ MGP_C3HHeJ_G0034370
protein coding gene Chr9:42630677-42637106 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035182
protein coding gene Chr9:43769626-43774846 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032095
protein coding gene Chr9:40920401-40925482 (+)
CAST/EiJ MGP_CASTEiJ_G0033693
protein coding gene Chr9:42473493-42479163 (+)
CBA/J MGP_CBAJ_G0034343
protein coding gene Chr9:45340464-45348291 (+)
DBA/2J MGP_DBA2J_G0034502
protein coding gene Chr9:41241109-41246299 (+)
FVB/NJ MGP_FVBNJ_G0034442
protein coding gene Chr9:40487798-40492867 (+)
LP/J MGP_LPJ_G0034583
protein coding gene Chr9:42795417-42801147 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034486
protein coding gene Chr9:47221962-47228095 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035201
protein coding gene Chr9:42077784-42083960 (+)
PWK/PhJ MGP_PWKPhJ_G0033398
protein coding gene Chr9:41104087-41109868 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033234
protein coding gene Chr9:42379469-42384690 (+)
WSB/EiJ MGP_WSBEiJ_G0033806
protein coding gene Chr9:42115743-42120975 (+)



Homology
more
  • Human Ortholog
    THY1, Thy-1 cell surface antigen
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THY1, Thy-1 cell surface antigen
  • Synonyms
    CD90, CDw90
  • Links
    NCBI Gene ID: 7070
    neXtProt AC: NX_P04216
    UniProt: P04216

  • Chr Location
    11q23.3; chr11:119415476-119424985 (-)  GRCh38

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    31 phenotypes from multigenic genotypes
    123 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable, fertile, and display no abnormalities in the brain and spinal cord, have normal axonal development and regeneration and no behavioral abnormalities. Long term potentiation is inhibited in the dentate gyrus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21838 NCBI Gene Model | MGI Sequence Detail 5196 C57BL/6J ±  kb
    transcript NM_009382 RefSeq | MGI Sequence Detail 1753 C57BL/6  
    polypeptide P01831 UniProt | EBI | MGI Sequence Detail 162 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 85
      Genomic 18
      cDNA 59
      Primer pair 7
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-15100, MGD-MRK-15102
    References
    more
    • Summaries
      All 294
      Developmental Gene Expression 47
      Diseases 2
      Gene Ontology 17
      Phenotypes 123
    • Earliest
      J:24839 REIF AE, et al., THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES. J Exp Med. 1964 Sep 1;120:413-33
    • Latest
      J:341132 Lee J, et al., Sex-Biased T-cell Exhaustion Drives Differential Immune Responses in Glioblastoma. Cancer Discov. 2023 Sep 6;13(9):2090-2105

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory