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Son Gene Detail
Summary
  • Symbol
    Son
  • Name
    Son DNA binding protein
  • Synonyms
    2900011L12Rik, mKIAA1019
  • Feature Type
    protein coding gene
  • IDs
    MGI:98353
    NCBI Gene: 20658
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:91444712-91476080 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 53.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    94 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98353
 protein coding gene Chr16:91444394-91476109 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023046
 protein coding gene Chr16:92675284-92709731 (+)
A/J MGP_AJ_G0023014
 protein coding gene Chr16:88340832-88373273 (+)
AKR/J MGP_AKRJ_G0022984
 protein coding gene Chr16:91010592-91042208 (+)
BALB/cJ MGP_BALBcJ_G0023016
 protein coding gene Chr16:88867966-88900363 (+)
C3H/HeJ MGP_C3HHeJ_G0022777
 protein coding gene Chr16:91585637-91618457 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023463
 protein coding gene Chr16:95668720-95701557 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020965
 protein coding gene Chr16:86038201-86070515 (+)
CAST/EiJ MGP_CASTEiJ_G0022296
 protein coding gene Chr16:92148320-92180574 (+)
CBA/J MGP_CBAJ_G0022746
 protein coding gene Chr16:99757677-99792088 (+)
DBA/2J MGP_DBA2J_G0022880
 protein coding gene Chr16:88244884-88277247 (+)
FVB/NJ MGP_FVBNJ_G0022854
 protein coding gene Chr16:87369763-87401800 (+)
LP/J MGP_LPJ_G0022950
 protein coding gene Chr16:92375384-92407127 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022875
 protein coding gene Chr16:104299538-104335919 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023481
 protein coding gene Chr16:91530677-91562550 (+)
PWK/PhJ MGP_PWKPhJ_G0022041
 protein coding gene Chr16:88423210-88456066 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021871
 protein coding gene Chr16:91091238-91125674 (+)
WSB/EiJ MGP_WSBEiJ_G0022348
 protein coding gene Chr16:91774681-91806342 (+)



Homology
more
  • Human Ortholog
    SON, SON DNA and RNA binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SON, SON DNA and RNA binding protein
  • Synonyms
    BASS1, C21orf50, DBP-5, NREBP, SON3, TOKIMS
  • Links
    NCBI Gene ID: 6651
    neXtProt AC: NX_P18583
    UniProt: P18583

  • Chr Location
    21q22.11; chr21:33543038-33577481 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SON associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1046
  • Tissues
    161
  • cDNA Data
    27
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20658 NCBI Gene Model | MGI Sequence Detail 31369 C57BL/6J ±  kb
transcript NM_178880 RefSeq | MGI Sequence Detail 8451 ZRU/MplStud  
polypeptide Q9QX47 UniProt | EBI | MGI Sequence Detail 2444 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    Genomic 1
    cDNA 29
    Primer pair 2
    Other 2

    Microarray probesets 11
Other
Accession IDs
less
MGD-MRK-14487, MGI:1915461, MGI:2146338, MGI:2146586, MGI:2146715
References
more
  • Summaries
    All 120
    Developmental Gene Expression 8
    Diseases 4
    Gene Ontology 7
    Phenotypes 76
  • Earliest
    J:12630 Cheng S, et al., GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome 16. Mamm Genome. 1993;4(6):338-42
  • Latest
    J:344656 Luo H, et al., SON is an essential m(6)A target for hematopoietic stem cell fate. Cell Stem Cell. 2023 Dec 7;30(12):1658-1673.e10
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory