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Shbg Gene Detail
Summary
  • Symbol
    Shbg
  • Name
    sex hormone binding globulin
  • Feature Type
    protein coding gene
  • IDs
    MGI:98295
    NCBI Gene: 20415
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69505630-69508731 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.86 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98295
 protein coding gene Chr11:69501108-69508852 (-)
129S1/SvImJ ENSMUSG00200044493
 protein coding gene Chr11:66451682-66454783 (-)
A/J ENSMUSG00195033572
 protein coding gene Chr11:66477520-66480819 (-)
AKR/J ENSMUSG00220040118
 protein coding gene Chr11:66586857-66589959 (-)
BALB/cJ ENSMUSG00180038237
 protein coding gene Chr11:66548325-66551426 (-)
C3H/HeJ ENSMUSG00175053863
 protein coding gene Chr11:66498573-66501675 (-)
C57BL/6NJ ENSMUSG00215053078
 protein coding gene Chr11:66274954-66278055 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016576
 protein coding gene Chr11:64351015-64354109 (-)
CAST/EiJ ENSTCUG00005053592
 protein coding gene Chr11:66038322-66041447 (-)
CBA/J ENSMUSG00210053096
 protein coding gene Chr11:66352655-66355756 (-)
DBA/2J ENSMUSG00185054877
 protein coding gene Chr11:66552293-66555355 (-)
FVB/NJ ENSMUSG00205051878
 protein coding gene Chr11:66443938-66447039 (-)
JF1/MsJ ENSUMUG00000056858
 protein coding gene Chr11:66950634-66953696 (-)
LP/J ENSMUSG00230053219
 protein coding gene Chr11:67662043-67665144 (-)
NOD/ShiLtJ ENSMUSG00190036801
 protein coding gene Chr11:66581545-66584646 (-)
NZO/HlLtJ ENSMUSG00225046946
 protein coding gene Chr11:69842987-69846288 (-)
PWK/PhJ ENSLUMG00010042199
 protein coding gene Chr11:66468703-66471782 (-)
SPRET/EiJ ENSMSPG00010046950
 protein coding gene Chr11:67194963-67198259 (-)
WSB/EiJ ENSIUOG00005039399
 protein coding gene Chr11:66481232-66484334 (-)



Homology
more
  • Human Ortholog
    SHBG, sex hormone binding globulin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SHBG, sex hormone binding globulin
  • Synonyms
    ABP, SBP, TEBG
  • Links
    NCBI Gene ID: 6462
    UniProt: P04278

  • Chr Location
    17p13.1; chr17:7613946-7633469 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SHBG associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    607
  • Tissues
    6
  • cDNA Data
    6
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005202 Ensembl Gene Model | MGI Sequence Detail 3102 C57BL/6J ±  kb
    transcript ENSMUST00000005334 Ensembl | MGI Sequence Detail 1419 Not Applicable  
    polypeptide ENSMUSP00000005334 Ensembl | MGI Sequence Detail 403 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 6
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14401
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:341688 Xie X, et al., SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice. FASEB J. 2023 May;37(5):e22918
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory