About   Help   FAQ
Sag Gene Detail
Summary
  • Symbol
    Sag
  • Name
    S-antigen, retina and pineal gland (arrestin)
  • Synonyms
    A930001K18Rik, Arr1, arrestin 1, rod arrestin, visual arrestin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98227
    NCBI Gene: 20215
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87731402-87772880 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.44 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    276 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98227
 protein coding gene Chr1:87731402-87772880 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016270
 protein coding gene Chr1:89176270-89232389 (+)
A/J MGP_AJ_G0016251
 protein coding gene Chr1:85832459-85881714 (+)
AKR/J MGP_AKRJ_G0016212
 protein coding gene Chr1:88372270-88421114 (+)
BALB/cJ MGP_BALBcJ_G0016208
 protein coding gene Chr1:85955300-85998995 (+)
C3H/HeJ MGP_C3HHeJ_G0016036
 protein coding gene Chr1:88630999-88693344 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016665
 protein coding gene Chr1:92483381-92536140 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014386
 protein coding gene Chr1:80286178-80327261 (+)
CAST/EiJ MGP_CASTEiJ_G0015621
 protein coding gene Chr1:87847833-87890388 (+)
CBA/J MGP_CBAJ_G0016012
 protein coding gene Chr1:95442961-95505393 (+)
DBA/2J MGP_DBA2J_G0016115
 protein coding gene Chr1:85127941-85172673 (+)
FVB/NJ MGP_FVBNJ_G0016114
 protein coding gene Chr1:84192379-84235150 (+)
LP/J MGP_LPJ_G0016186
 protein coding gene Chr1:90227822-90268547 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016140
 protein coding gene Chr1:98703564-98761706 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016707
 protein coding gene Chr1:88488722-88534415 (+)
PWK/PhJ MGP_PWKPhJ_G0015408
 protein coding gene Chr1:84442278-84483734 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015188
 protein coding gene Chr1:87381831-87426491 (+)
WSB/EiJ MGP_WSBEiJ_G0015685
 protein coding gene Chr1:88151125-88196400 (+)



Homology
more
  • Human Ortholog
    SAG, S-antigen visual arrestin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAG, S-antigen visual arrestin
  • Synonyms
    RP47, RP96, S-AG
  • Links
    NCBI Gene ID: 6295
    neXtProt AC: NX_P10523
    UniProt: P10523

  • Chr Location
    2q37.1; chr2:233307816-233347055 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human SAG associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormalities in retinal rod cell outer segment morphology and rod electrophysiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    17
  • cDNA Data
    129
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20215 NCBI Gene Model | MGI Sequence Detail 41479 C57BL/6J ±  kb
    transcript NM_009118 RefSeq | MGI Sequence Detail 1718 ZRU/MplStud  
    polypeptide P20443 UniProt | EBI | MGI Sequence Detail 403 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      Genomic 8
      cDNA 130
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14285, MGI:2442817
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 58
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:332394 Tan M, et al., The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model. Cell Rep. 2022 Dec 20;41(12):111837
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory