About   Help   FAQ
Pdc Gene Detail
Summary
  • Symbol
    Pdc
  • Name
    phosducin
  • Synonyms
    Pdc, Rpr1, Rpr-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98090
    NCBI Gene: 20028
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:150195168-150209657 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 63.84 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    320 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98090
 protein coding gene Chr1:150195168-150209657 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016574
 protein coding gene Chr1:154968000-154984308 (+)
A/J MGP_AJ_G0016556
 protein coding gene Chr1:148721386-148735850 (+)
AKR/J MGP_AKRJ_G0016521
 protein coding gene Chr1:153276223-153292939 (+)
BALB/cJ MGP_BALBcJ_G0016516
 protein coding gene Chr1:149253960-149268706 (+)
C3H/HeJ MGP_C3HHeJ_G0016341
 protein coding gene Chr1:153447717-153462177 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016977
 protein coding gene Chr1:160339589-160354350 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014686
 protein coding gene Chr1:141085319-141101093 (+)
CAST/EiJ MGP_CASTEiJ_G0015920
 protein coding gene Chr1:152843552-152861489 (+)
CBA/J MGP_CBAJ_G0016315
 protein coding gene Chr1:165996767-166014397 (+)
DBA/2J MGP_DBA2J_G0016421
 protein coding gene Chr1:147772068-147786691 (+)
FVB/NJ MGP_FVBNJ_G0016419
 protein coding gene Chr1:146198856-146213338 (+)
LP/J MGP_LPJ_G0016492
 protein coding gene Chr1:156002555-156020133 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016445
 protein coding gene Chr1:173697466-173716888 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017013
 protein coding gene Chr1:153074663-153089712 (+)
PWK/PhJ MGP_PWKPhJ_G0015706
 protein coding gene Chr1:146695489-146710517 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015494
 protein coding gene Chr1:151881899-151899533 (+)
WSB/EiJ MGP_WSBEiJ_G0015983
 protein coding gene Chr1:153162428-153177546 (+)



Homology
more
  • Human Ortholog
    PDC, phosducin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDC, phosducin
  • Synonyms
    MEKA, PHD, PhLOP, PhLP
  • Links
    NCBI Gene ID: 5132
    neXtProt AC: NX_P20941
    UniProt: P20941

  • Chr Location
    1q31.1; chr1:186443566-186461114 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display normal retinal morphology and rod function with reduced transducin (Gnat1) translocation. Mice homozygous for a different knock-out allele exhibit large pupils, increased blood pressure, age-related vascular smooth muscle hypertrophy, and stress-induced hypertension.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    16
  • cDNA Data
    106
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20028 NCBI Gene Model | MGI Sequence Detail 14490 C57BL/6J ±  kb
    transcript NM_001159730 RefSeq | MGI Sequence Detail 1263 ZRU/MplStud  
    polypeptide Q9QW08 UniProt | EBI | MGI Sequence Detail 244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 1
      cDNA 108
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13205, MGD-MRK-14115, MGD-MRK-14116
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:11278 Danciger M, et al., The gene for retinal rod 33-kDa protein is on mouse chromosome 1, near Lamb2. Cytogenet Cell Genet. 1991;56(3-4):202-5
    • Latest
      J:301112 Maddala R, et al., Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract. Sci Rep. 2021 Jan 26;11(1):2203
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory