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Ptn Gene Detail
Summary
  • Symbol
    Ptn
  • Name
    pleiotrophin
  • Synonyms
    HB-GAM, HBGF-8, HBNF, heparin-binding growth-associated molecule, heparin-binding growth factor 8, Osf-1, Osf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97804
    NCBI Gene: 19242
  • Alliance
    genome feature page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:36691863-36787114 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 15.48 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2662 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    3
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97804
 protein coding gene Chr6:36691863-36787155 (-)
129S1/SvImJ ENSMUSG00200044834
 protein coding gene Chr6:33738293-33833641 (-)
A/J ENSMUSG00195032390
 protein coding gene Chr6:33715568-33810971 (-)
AKR/J ENSMUSG00220006698
 protein coding gene Chr6:33314235-33409645 (-)
BALB/cJ ENSMUSG00180043244
 protein coding gene Chr6:33844368-33939752 (-)
C3H/HeJ ENSMUSG00175044118
 protein coding gene Chr6:33672684-33768100 (-)
C57BL/6NJ ENSMUSG00215042441
 protein coding gene Chr6:33750499-33845870 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028223
 protein coding gene Chr6:31333832-31424971 (-)
CAST/EiJ ENSTCUG00005032488
 protein coding gene Chr6:33238159-33333981 (-)
CBA/J ENSMUSG00210051946
 protein coding gene Chr6:33729991-33825401 (-)
DBA/2J ENSMUSG00185039508
 protein coding gene Chr6:33830899-33926295 (-)
FVB/NJ ENSMUSG00205020592
 protein coding gene Chr6:33796270-33891704 (-)
JF1/MsJ ENSUMUG00000007331
 protein coding gene Chr6:33487169-33583030 (-)
LP/J ENSMUSG00230038129
 protein coding gene Chr6:34744429-34839772 (-)
NOD/ShiLtJ ENSMUSG00190046732
 protein coding gene Chr6:33596748-33692146 (-)
NZO/HlLtJ ENSMUSG00225009432
 protein coding gene Chr6:36732425-36827797 (-)
PWK/PhJ ENSLUMG00010045433
 protein coding gene Chr6:33234135-33330491 (-)
SPRET/EiJ ENSMSPG00010022685
 protein coding gene Chr6:33809569-33905810 (-)
WSB/EiJ ENSIUOG00005027898
 protein coding gene Chr6:33916058-34011429 (-)



Homology
more
  • Human Ortholog
    PTN, pleiotrophin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTN, pleiotrophin
  • Synonyms
    HARP, HBBM, HB-GAM, HBGF-8, HBGF8, HBNF, HBNF-1, NEGF1, OSF-1
  • Links
    NCBI Gene ID: 5764
    UniProt: P21246

  • Chr Location
    7q33; chr7:137227341-137344358 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PTN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit enhanced long term potentiation, an impairment of spatial learning, and increased anxiety. The brains of mutant mice are morphologically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    126
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1110
  • Tissues
    328
  • cDNA Data
    133
  • Literature Summary
    48
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19242 NCBI Gene Model | MGI Sequence Detail 95252 C57BL/6J ±  kb
    transcript NM_008973 RefSeq | MGI Sequence Detail 1588 ZRU/MplStud  
    polypeptide P63089 UniProt | EBI | MGI Sequence Detail 168 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000013438 pleiotrophin
      (term hierarchy)
    • InterPro Domains
      IPR000762 Midkine heparin-binding growth factor
      IPR020090 Pleiotrophin/Midkine, C-terminal domain
      IPR038130 Pleiotrophin/Midkine, C-terminal domain superfamily
      IPR020091 Pleiotrophin/Midkine disulphide-rich domain superfamily
      IPR020092 Pleiotrophin/Midkine heparin-binding growth factor, conserved site
      IPR020089 Pleiotrophin/Midkine, N-terminal domain
      IPR037122 Pleiotrophin/Midkine, N-terminal domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 156
      Genomic 4
      cDNA 135
      Primer pair 11
      Other 6
      Antibodies 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13056, MGD-MRK-13057, MGD-MRK-13672
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 48
      Gene Ontology 22
      Phenotypes 41
    • Earliest
      J:10881 Tezuka K, et al., Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues. Biochem Biophys Res Commun. 1990 Nov 30;173(1):246-51
    • Latest
      J:387130 Yea JH, et al., Signaling and transcriptional networks governing late synovial joint development. Dev Biol. 2026 Sep;537:28-38
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory