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Serpinb2 Gene Detail
Summary
  • Symbol
    Serpinb2
  • Name
    serine (or cysteine) peptidase inhibitor, clade B, member 2
  • Synonyms
    ovalbumin, PAI-2, Planh2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97609
    NCBI Gene: 18788
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:107439153-107453330 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 50.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    564 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97609
 protein coding gene Chr1:107439153-107463208 (+)
129S1/SvImJ ENSMUSG00200000343
 protein coding gene Chr1:104740382-104753612 (+)
A/J ENSMUSG00195007613
 protein coding gene Chr1:104227664-104259271 (+)
AKR/J ENSMUSG00220000165
 protein coding gene Chr1:104242132-104273740 (+)
BALB/cJ ENSMUSG00180000394
 protein coding gene Chr1:104513426-104545030 (+)
C3H/HeJ ENSMUSG00175000540
 protein coding gene Chr1:104442741-104474336 (+)
C57BL/6NJ ENSMUSG00215006115
 protein coding gene Chr1:104438437-104470061 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014499
 protein coding gene Chr1:100049735-100073702 (+)
CAST/EiJ ENSTCUG00005002733
 protein coding gene Chr1:103770078-103801770 (+)
CBA/J ENSMUSG00210000055
 protein coding gene Chr1:104322835-104354421 (+)
DBA/2J ENSMUSG00185007771
 protein coding gene Chr1:108763643-108776867 (+)
FVB/NJ ENSMUSG00205007895
 protein coding gene Chr1:103625990-103657597 (+)
JF1/MsJ ENSUMUG00000000119
 protein coding gene Chr1:107370755-107402181 (+)
LP/J ENSMUSG00230000090
 protein coding gene Chr1:108026343-108039573 (+)
NOD/ShiLtJ ENSMUSG00190000317
 protein coding gene Chr1:104375230-104406849 (+)
NZO/HlLtJ ENSMUSG00225000285
 protein coding gene Chr1:111929642-111961613 (+)
PWK/PhJ ENSLUMG00010000114
 protein coding gene Chr1:103760855-103792284 (+)
SPRET/EiJ ENSMSPG00010000457
 protein coding gene Chr1:106005742-106024225 (+)
WSB/EiJ ENSIUOG00005000953
 protein coding gene Chr1:104121528-104152761 (+)



Homology
more
  • Human Ortholog
    SERPINB2, serpin family B member 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINB2, serpin family B member 2
  • Synonyms
    HsT1201, PAI, PAI-2, PAI2, PLANH2
  • Links
    NCBI Gene ID: 5055
    UniProt: P05120

  • Chr Location
    18q21.33-q22.1; chr18:63871692-63903888 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to a slight to mild reduction in platelet, lymphocyte, neutrophil, and monocyte cell number.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    685
  • Tissues
    63
  • cDNA Data
    17
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18788 NCBI Gene Model | MGI Sequence Detail 14178 C57BL/6J ±  kb
    transcript NM_011111 RefSeq | MGI Sequence Detail 2007 ZRU/MplStud  
    polypeptide P12388 UniProt | EBI | MGI Sequence Detail 415 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 2
      cDNA 18
      Primer pair 3
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13345
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 9
      Gene Ontology 4
      Phenotypes 30
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:387086 Vasamsetti SB, et al., Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation. Nat Commun. 2026 Feb 12;17(1):1493
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory