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Pkm Gene Detail
Summary
  • Symbol
    Pkm
  • Name
    pyruvate kinase, muscle
  • Synonyms
    Pk-2, Pk3, Pk-3, Pkm2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97591
    NCBI Gene: 18746
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:59563859-59586655 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 32.03 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97591
protein coding gene Chr9:59563651-59586658 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034904
protein coding gene Chr9:59017056-59041467 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0034814
protein coding gene Chr9:58440721-58469720 (+)
BALB/cJ MGP_BALBcJ_G0034877
protein coding gene Chr9:56857371-56880378 (+)
C3H/HeJ MGP_C3HHeJ_G0034587
protein coding gene Chr9:58936228-58959091 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035396
protein coding gene Chr9:60649361-60672356 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032307
protein coding gene Chr9:56857085-56880199 (+)
CAST/EiJ MGP_CASTEiJ_G0033908
protein coding gene Chr9:59026509-59049439 (+)
CBA/J MGP_CBAJ_G0034558
protein coding gene Chr9:62791832-62817638 (+)
DBA/2J MGP_DBA2J_G0034717
protein coding gene Chr9:56940990-56963722 (+)
FVB/NJ MGP_FVBNJ_G0034659
protein coding gene Chr9:56201616-56224780 (+)
LP/J MGP_LPJ_G0034800
protein coding gene Chr9:59320722-59343561 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034702
protein coding gene Chr9:64225307-64249263 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035418
protein coding gene Chr9:58452887-58477464 (+)
PWK/PhJ MGP_PWKPhJ_G0033612
protein coding gene Chr9:57002107-57025915 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0034021
protein coding gene Chr9:58398341-58426950 (+)



Homology
more
  • Human Ortholog
    PKM, pyruvate kinase M1/2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PKM, pyruvate kinase M1/2
  • Synonyms
    CTHBP, HEL-S-30, OIP3, p58, PK3, PKM2, TCB, THBP1
  • Links
    NCBI Gene ID: 5315
    neXtProt AC: NX_P14618
    UniProt: P14618

  • Chr Location
    15q23; chr15:72199029-72231819 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele exhibit prenatal lethality around the time of implanatation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18746 NCBI Gene Model | MGI Sequence Detail 22797 C57BL/6J ±  kb
transcript NM_001378871 RefSeq | MGI Sequence Detail 3587 ZRU/MplStud  
polypeptide P52480 UniProt | EBI | MGI Sequence Detail 531 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 40
    cDNA 34
    Primer pair 6

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13319, MGD-MRK-13320, MGD-MRK-13322, MGI:2143183, MGI:2143184, MGI:2144733
References
more
  • Summaries
    All 167
    Developmental Gene Expression 27
    Gene Ontology 20
    Phenotypes 61
  • Earliest
    J:5994 Lalley PA, et al., Conservation of autosomal gene synteny groups in mouse and man. Nature. 1978 Jul 13;274(5667):160-3
  • Latest
    J:342138 Hu X, et al., Fibrinogen-like protein 2 regulates macrophage glycolytic reprogramming by directly targeting PKM2 and exacerbates alcoholic liver injury. Int Immunopharmacol. 2023 Sep 19;124(Pt B):110957

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory