About   Help   FAQ
Pcp4 Gene Detail
Summary
  • Symbol
    Pcp4
  • Name
    Purkinje cell protein 4
  • Synonyms
    P16Rimb19, Pcp-4, Pep19
  • Feature Type
    protein coding gene
  • IDs
    MGI:97509
    NCBI Gene: 18546
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:96268806-96326993 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 56.97 cM
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    552 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97509
 protein coding gene Chr16:96268806-96326993 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023087
 protein coding gene Chr16:97852209-97912619 (+)
A/J MGP_AJ_G0023055
 protein coding gene Chr16:93221109-93280342 (+)
AKR/J MGP_AKRJ_G0023025
 protein coding gene Chr16:96086839-96147937 (+)
BALB/cJ MGP_BALBcJ_G0023057
 protein coding gene Chr16:93772668-93831685 (+)
C3H/HeJ MGP_C3HHeJ_G0022818
 protein coding gene Chr16:96613959-96674232 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023504
 protein coding gene Chr16:100950879-101010443 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021006
 protein coding gene Chr16:91062703-91121384 (+)
CAST/EiJ MGP_CASTEiJ_G0022338
 protein coding gene Chr16:97413413-97474374 (+)
CBA/J MGP_CBAJ_G0022787
 protein coding gene Chr16:105314316-105377434 (+)
DBA/2J MGP_DBA2J_G0022921
 protein coding gene Chr16:93096245-93154273 (+)
FVB/NJ MGP_FVBNJ_G0022895
 protein coding gene Chr16:92267333-92325733 (+)
LP/J MGP_LPJ_G0022991
 protein coding gene Chr16:97492726-97553451 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022916
 protein coding gene Chr16:109525153-109586831 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023522
 protein coding gene Chr16:96622197-96681282 (+)
PWK/PhJ MGP_PWKPhJ_G0022082
 protein coding gene Chr16:93387799-93448700 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021912
 protein coding gene Chr16:96162984-96225014 (+)
WSB/EiJ MGP_WSBEiJ_G0022388
 protein coding gene Chr16:96889805-96951997 (+)



Homology
more
  • Human Ortholog
    PCP4, Purkinje cell protein 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCP4, Purkinje cell protein 4
  • Synonyms
    PEP-19
  • Links
    NCBI Gene ID: 5121
    neXtProt AC: NX_P48539
    UniProt: P48539

  • Chr Location
    21q22.2; chr21:39867438-39929397 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired motor learning and abnormal synaptic plasticity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1327
  • Tissues
    305
  • cDNA Data
    19
  • Literature Summary
    39
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 18546 NCBI Gene Model | MGI Sequence Detail 58188 C57BL/6J ±  kb
transcript NM_008791 RefSeq | MGI Sequence Detail 658 Not Specified  
polypeptide P63054 UniProt | EBI | MGI Sequence Detail 62 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    Genomic 8
    cDNA 20
    Primer pair 8
    Other 5

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13098, MGD-MRK-13184, MGD-MRK-13187
References
more
  • Summaries
    All 161
    Developmental Gene Expression 39
    Diseases 6
    Gene Ontology 5
    Phenotypes 87
  • Earliest
    J:14637 Oberdick J, et al., A Purkinje cell differentiation marker shows a partial DNA sequence homology to the cellular sis/PDGF2 gene [published erratum appears in Neuron 1989 Sep;3(3):following 385]. Neuron. 1988 Jul;1(5):367-76
  • Latest
    J:345472 Lana-Elola E, et al., Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome. Sci Transl Med. 2024 Jan 24;16(731):eadd6883
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory