About   Help   FAQ
Pcp2 Gene Detail
Summary
  • Symbol
    Pcp2
  • Name
    Purkinje cell protein 2 (L7)
  • Synonyms
    L7, Pcp-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97508
    NCBI Gene: 18545
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:3673371-3675545 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 1.92 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97508
 protein coding gene Chr8:3673369-3675547 (-)
129S1/SvImJ ENSMUSG00200011900
 protein coding gene Chr8:494422-496614 (-)
A/J ENSMUSG00195010058
 protein coding gene Chr8:898628-900802 (-)
AKR/J ENSMUSG00220010255
 protein coding gene Chr8:625159-627333 (-)
BALB/cJ ENSMUSG00180003995
 protein coding gene Chr8:549097-551277 (-)
C3H/HeJ ENSMUSG00175007670
 protein coding gene Chr8:663721-665895 (-)
C57BL/6NJ ENSMUSG00215005115
 protein coding gene Chr8:578073-580247 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030777
 protein coding gene Chr8:489967-492180 (-)
CAST/EiJ ENSTCUG00005019977
 protein coding gene Chr8:636095-638230 (-)
CBA/J ENSMUSG00210010544
 protein coding gene Chr8:541296-543472 (-)
DBA/2J ENSMUSG00185003516
 protein coding gene Chr8:677338-679512 (-)
FVB/NJ ENSMUSG00205005419
 protein coding gene Chr8:611167-613341 (-)
JF1/MsJ ENSUMUG00000020566
 protein coding gene Chr8:631073-633263 (-)
LP/J ENSMUSG00230006119
 protein coding gene Chr8:2846928-2849102 (-)
NOD/ShiLtJ ENSMUSG00190010393
 protein coding gene Chr8:651357-653531 (-)
NZO/HlLtJ ENSMUSG00225016453
 protein coding gene Chr8:10712439-10714610 (-)
PWK/PhJ ENSLUMG00010009502
 protein coding gene Chr8:588275-590469 (-)
SPRET/EiJ ENSMSPG00010015579
 protein coding gene Chr8:555485-557676 (-)
WSB/EiJ ENSIUOG00005004377
 protein coding gene Chr8:586094-588267 (-)



Homology
more
  • Human Ortholog
    PCP2, Purkinje cell protein 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCP2, Purkinje cell protein 2
  • Synonyms
    GPSM4, PCD5
  • Links
    NCBI Gene ID: 126006
    UniProt: Q8IVA1

  • Chr Location
    19p13.2; chr19:7631611-7637006 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    31 phenotype references
Mice homozygous for a null mutation do not exhibit any detectable abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    664
  • Tissues
    38
  • cDNA Data
    12
  • Literature Summary
    17
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004630 Ensembl Gene Model | MGI Sequence Detail 2175 C57BL/6J ±  kb
transcript ENSMUST00000136105 Ensembl | MGI Sequence Detail 504 Not Applicable  
polypeptide ENSMUSP00000121079 Ensembl | MGI Sequence Detail 136 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 2
    cDNA 13
    Primer pair 4
    Other 2

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-13183, MGD-MRK-13186
References
more
  • Summaries
    All 83
    Developmental Gene Expression 17
    Gene Ontology 4
    Phenotypes 31
  • Earliest
    J:9499 Nordquist DT, et al., cDNA cloning and characterization of three genes uniquely expressed in cerebellum by Purkinje neurons. J Neurosci. 1988 Dec;8(12):4780-9
  • Latest
    J:370996 Khouri-Farah N, et al., FOXP genes regulate Purkinje cell diversity and cerebellar morphogenesis. Nat Neurosci. 2025 Aug 18;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory