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Nid1 Gene Detail
Summary
  • Symbol
    Nid1
  • Name
    nidogen 1
  • Synonyms
    entactin, entactin 1, entactin-1, nidogen-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97342
    NCBI Gene: 18073
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr13:13612252-13686849 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 5.26 cM
  • Mapping Data
    30 experiments
Strain
Comparison
more
  • SNPs within 2kb
    321 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97342
 protein coding gene Chr13:13612136-13686854 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020233
 protein coding gene Chr13:9525873-10457040 (+)
A/J MGP_AJ_G0020192
 protein coding gene Chr13:10321973-10392506 (+)
AKR/J MGP_AKRJ_G0020166
 protein coding gene Chr13:10431103-10519277 (+)
BALB/cJ MGP_BALBcJ_G0020179
 protein coding gene Chr13:10349629-10398182 (+)
C3H/HeJ MGP_C3HHeJ_G0019979
 protein coding gene Chr13:9657989-10669650 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020622
 protein coding gene Chr13:10923239-11017520 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018228
 protein coding gene Chr13:9117827-9189831 (+)
CAST/EiJ MGP_CASTEiJ_G0019516
 protein coding gene Chr13:10230659-10309957 (+)
CBA/J MGP_CBAJ_G0019946
 protein coding gene Chr13:11276577-11369265 (+)
DBA/2J MGP_DBA2J_G0020065
 protein coding gene Chr13:9988740-10064572 (+)
FVB/NJ MGP_FVBNJ_G0020047
 protein coding gene Chr13:9742401-9791307 (+)
LP/J MGP_LPJ_G0020136
 protein coding gene Chr13:10585347-10643111 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020082
 protein coding gene Chr13:10477742-11461603 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020649
 protein coding gene Chr13:10179952-10307815 (+)
PWK/PhJ MGP_PWKPhJ_G0019279
 protein coding gene Chr13:10072395-10155944 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019086
 protein coding gene Chr13:9386420-9534022 (+)
WSB/EiJ MGP_WSBEiJ_G0019577
 protein coding gene Chr13:10254628-10340937 (+)



Homology
more
  • Human Ortholog
    NID1, nidogen 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NID1, nidogen 1
  • Synonyms
    NID
  • Links
    NCBI Gene ID: 4811
    neXtProt AC: NX_P14543
    UniProt: P14543

  • Chr Location
    1q42.3; chr1:235975830-236065109 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neurologic deficits including seizure-like symptoms and loss of muscle control in the hind legs, and show altered basement membrane morphology in selected locations including brain capillaries and the lens capsule.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1295
  • Tissues
    256
  • cDNA Data
    197
  • Literature Summary
    112
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18073 NCBI Gene Model | MGI Sequence Detail 74598 C57BL/6J ±  kb
    transcript NM_010917 RefSeq | MGI Sequence Detail 5970 ZRU/MplStud  
    polypeptide P10493 UniProt | EBI | MGI Sequence Detail 1245 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 235
      Genomic 28
      cDNA 198
      Primer pair 7
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12878
    References
    more
    • Summaries
      All 196
      Developmental Gene Expression 112
      Gene Ontology 31
      Phenotypes 17
    • Earliest
      J:320095 Paulsson M, et al., Laminin-nidogen complex. Extraction with chelating agents and structural characterization. Eur J Biochem. 1987 Jul 1;166(1):11-9
    • Latest
      J:333810 Elenbaas JS, et al., SVEP1 is an endogenous ligand for the orphan receptor PEAR1. Nat Commun. 2023 Feb 15;14(1):850
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory