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Myf5 Gene Detail
Summary
  • Symbol
    Myf5
  • Name
    myogenic factor 5
  • Synonyms
    B130010J22Rik, bHLHc2, Myf-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:97252
    NCBI Gene: 17877
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:107318769-107321995 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 55.95 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97252
 protein coding gene Chr10:107318769-107322787 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017708
 protein coding gene Chr10:109676370-109679566 (-)
A/J MGP_AJ_G0017685
 protein coding gene Chr10:105569055-105572302 (-)
AKR/J MGP_AKRJ_G0017647
 protein coding gene Chr10:108635971-108639214 (-)
BALB/cJ MGP_BALBcJ_G0017649
 protein coding gene Chr10:105958624-105961840 (-)
C3H/HeJ MGP_C3HHeJ_G0017474
 protein coding gene Chr10:108730830-108734076 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018106
 protein coding gene Chr10:113477036-113480251 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015785
 protein coding gene Chr10:100488115-100491322 (-)
CAST/EiJ MGP_CASTEiJ_G0017035
 protein coding gene Chr10:108837453-108841229 (-)
CBA/J MGP_CBAJ_G0017443
 protein coding gene Chr10:117893815-117897104 (-)
DBA/2J MGP_DBA2J_G0017548
 protein coding gene Chr10:104710689-104713947 (-)
FVB/NJ MGP_FVBNJ_G0017542
 protein coding gene Chr10:103706468-103709693 (-)
LP/J MGP_LPJ_G0017622
 protein coding gene Chr10:110295792-110299036 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0018144
 protein coding gene Chr10:108625749-108628975 (-)
PWK/PhJ MGP_PWKPhJ_G0016817
 protein coding gene Chr10:104762788-104766265 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016607
 protein coding gene Chr10:107372222-107375442 (-)
WSB/EiJ MGP_WSBEiJ_G0017095
 protein coding gene Chr10:108739036-108742266 (-)



Homology
more
  • Human Ortholog
    MYF5, myogenic factor 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYF5, myogenic factor 5
  • Synonyms
    bHLHc2, EORVA
  • Links
    NCBI Gene ID: 4617
    neXtProt AC: NX_P13349
    UniProt: P13349

  • Chr Location
    12q21.31; chr12:80716912-80719671 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 10 alleles in 9 genetic backgrounds
    147 phenotypes from multigenic genotypes
    289 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit delayed appearance of myotomal cells in somites, and lack the distal portion of ribs resulting in inability to breathe and lethality at birth. Other mutants lack the rib phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1946
  • Tissues
    488
  • cDNA Data
    21
  • Literature Summary
    265
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000435 Ensembl Gene Model | MGI Sequence Detail 3227 C57BL/6J ±  kb
    transcript ENSMUST00000000445 Ensembl | MGI Sequence Detail 2083 Not Applicable  
    polypeptide ENSMUSP00000000445 Ensembl | MGI Sequence Detail 255 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 92
      Genomic 13
      cDNA 29
      Primer pair 20
      Other 30

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12738, MGI:2445029
    References
    more
    • Summaries
      All 562
      Developmental Gene Expression 265
      Diseases 4
      Gene Ontology 16
      Phenotypes 289
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:344130 Jama A, et al., Lipin1 plays complementary roles in myofibre stability and regeneration in dystrophic muscles. J Physiol. 2023 Mar;601(5):961-978
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory