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Msmb Gene Detail
Summary
  • Symbol
    Msmb
  • Name
    beta-microseminoprotein
  • Synonyms
    beta-inhibin, beta-MSP, PIP, prostatic inhibin protein, PSP94
  • Feature Type
    protein coding gene
  • IDs
    MGI:97166
    NCBI Gene: 17695
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:31863980-31880284 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.40 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97166
 protein coding gene Chr14:31863980-31880327 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021138
 protein coding gene Chr14:25374770-25391336 (+)
A/J MGP_AJ_G0021086
 protein coding gene Chr14:24405138-24421474 (+)
AKR/J MGP_AKRJ_G0021063
 protein coding gene Chr14:25551747-25568079 (+)
BALB/cJ MGP_BALBcJ_G0021090
 protein coding gene Chr14:24580916-24597252 (+)
C3H/HeJ MGP_C3HHeJ_G0020873
 protein coding gene Chr14:25428236-25444570 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021522
 protein coding gene Chr14:26385138-26401479 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019085
 protein coding gene Chr14:24469485-24486345 (+)
CAST/EiJ MGP_CASTEiJ_G0020398
 protein coding gene Chr14:25216694-25235536 (+)
CBA/J MGP_CBAJ_G0020840
 protein coding gene Chr14:27375273-27391602 (+)
DBA/2J MGP_DBA2J_G0020962
 protein coding gene Chr14:24438153-24454483 (+)
FVB/NJ MGP_FVBNJ_G0020946
 protein coding gene Chr14:24397831-24414170 (+)
LP/J MGP_LPJ_G0021031
 protein coding gene Chr14:25693449-25712569 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020972
 protein coding gene Chr14:26613605-26629935 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021555
 protein coding gene Chr14:25326144-25342480 (+)
PWK/PhJ MGP_PWKPhJ_G0020146
 protein coding gene Chr14:23908487-23925003 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019970
 protein coding gene Chr14:24932598-24949126 (+)
WSB/EiJ MGP_WSBEiJ_G0020453
 protein coding gene Chr14:25387849-25404447 (+)



Homology
more
  • Human Ortholog
    MSMB, microseminoprotein beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MSMB, microseminoprotein beta
  • Synonyms
    HPC13, IGBF, MSP, MSPB, PN44, PRPS, PSP, PSP57, PSP94, PSP-94
  • Links
    NCBI Gene ID: 4477
    neXtProt AC: NX_P08118
    UniProt: P08118

  • Chr Location
    10q11.22; chr10:46033307-46048180 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Msmb mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit early prostate cancer development progressing from intraepithelial neoplasia with microinvasion to well-differentiated prostate gland adenocarcinoma, and show enlargement of the prostate gland and the lymph nodes, and increased metastatic potential.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    6
  • cDNA Data
    2
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17695 NCBI Gene Model | MGI Sequence Detail 16305 C57BL/6J ±  kb
    transcript NM_020597 RefSeq | MGI Sequence Detail 522 C57BL/6  
    polypeptide O08540 UniProt | EBI | MGI Sequence Detail 113 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 2
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12565
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 1
      Phenotypes 18
    • Earliest
      J:434 Ulvsback M, et al., Assignment of the human gene for beta-microseminoprotein (MSMB) to chromosome 10 and demonstration of related genes in other vertebrates. Genomics. 1991 Dec;11(4):920-4
    • Latest
      J:238425 Bernichtein S, et al., Vitamin D3 Prevents Calcium-Induced Progression of Early-Stage Prostate Tumors by Counteracting TRPC6 and Calcium Sensing Receptor Upregulation. Cancer Res. 2017 Jan 15;77(2):355-365
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory