About   Help   FAQ
Mep1b Gene Detail
Summary
  • Symbol
    Mep1b
  • Name
    meprin 1 beta
  • Synonyms
    Mep-1b, meprin beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:96964
    NCBI Gene: 17288
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:21205401-21233256 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 11.81 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    753 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96964
 protein coding gene Chr18:21194980-21233256 (+)
129S1/SvImJ ENSMUSG00200019323
 protein coding gene Chr18:18202519-18240800 (+)
A/J ENSMUSG00195002152
 protein coding gene Chr18:18347841-18386119 (+)
AKR/J ENSMUSG00220011282
 protein coding gene Chr18:18354838-18393114 (+)
BALB/cJ ENSMUSG00180003895
 protein coding gene Chr18:18809035-18847314 (+)
C3H/HeJ ENSMUSG00175004363
 protein coding gene Chr18:18296206-18334482 (+)
C57BL/6NJ ENSMUSG00215003546
 protein coding gene Chr18:18048016-18086293 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022035
 protein coding gene Chr18:17318189-17346806 (+)
CAST/EiJ ENSTCUG00005014365
 protein coding gene Chr18:18091529-18129895 (+)
CBA/J ENSMUSG00210020179
 protein coding gene Chr18:18353802-18392144 (+)
DBA/2J ENSMUSG00185007791
 protein coding gene Chr18:18311096-18349438 (+)
FVB/NJ ENSMUSG00205015636
 protein coding gene Chr18:18043371-18081706 (+)
JF1/MsJ ENSUMUG00000023441
 protein coding gene Chr18:18377343-18415644 (+)
LP/J ENSMUSG00230005921
 protein coding gene Chr18:20398677-20436952 (+)
NOD/ShiLtJ ENSMUSG00190017091
 protein coding gene Chr18:18125714-18164064 (+)
NZO/HlLtJ ENSMUSG00225025182
 protein coding gene Chr18:20321704-20359980 (+)
PWK/PhJ ENSLUMG00010015581
 protein coding gene Chr18:18559914-18598273 (+)
SPRET/EiJ ENSMSPG00010004677
 protein coding gene Chr18:18448672-18492148 (+)
WSB/EiJ ENSIUOG00005019149
 protein coding gene Chr18:18146541-18184814 (+)



Homology
more
  • Human Ortholog
    MEP1B, meprin A subunit beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEP1B, meprin A subunit beta
  • Links
    NCBI Gene ID: 4225
    UniProt: Q16820

  • Chr Location
    18q12.1; chr18:32185069-32220404 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 4 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit 50% prenatal lethality; survivors have reduced birth weight and show altered renal gene expression, but otherwise are apparently normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    635
  • Tissues
    12
  • cDNA Data
    41
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17288 NCBI Gene Model | MGI Sequence Detail 27856 C57BL/6J ±  kb
    transcript NM_008586 RefSeq | MGI Sequence Detail 2286 Not Specified  
    polypeptide Q61847 UniProt | EBI | MGI Sequence Detail 704 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 1
      cDNA 44

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12195, MGD-MRK-12198
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 33
    • Earliest
      J:17708 Gorbea CM, et al., Homo- and heterotetrameric forms of the membrane-bound metalloendopeptidases meprin A and B. Arch Biochem Biophys. 1991 Nov 1;290(2):549-53
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory