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Mcpt1 Gene Detail
Summary
  • Symbol
    Mcpt1
  • Name
    mast cell protease 1
  • Synonyms
    Mcp-1, vascular chymase
  • Feature Type
    protein coding gene
  • IDs
    MGI:96937
    NCBI Gene: 17224
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56255428-56257841 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96937
 protein coding gene Chr14:56255421-56257848 (+)
129S1/SvImJ ENSMUSG00200040586
 protein coding gene Chr14:44843208-44845621 (+)
A/J ENSMUSG00195030278
 protein coding gene Chr14:45059952-45062365 (+)
AKR/J ENSMUSG00220023703
 protein coding gene Chr14:44387818-44390231 (+)
BALB/cJ ENSMUSG00180050938
 protein coding gene Chr14:44683634-44686047 (+)
C3H/HeJ ENSMUSG00175049398
 protein coding gene Chr14:46365957-46368370 (+)
C57BL/6NJ ENSMUSG00215046012
 protein coding gene Chr14:44578709-44581122 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005045527
 protein coding gene Chr14:46352693-46355106 (+)
CBA/J ENSMUSG00210043522
 protein coding gene Chr14:45046513-45048926 (+)
DBA/2J ENSMUSG00185051701
 protein coding gene Chr14:50113667-50116077 (+)
FVB/NJ ENSMUSG00205018330
 protein coding gene Chr14:44449325-44451738 (+)
JF1/MsJ ENSUMUG00000032728
 protein coding gene Chr14:61333662-61336072 (+)
LP/J ENSMUSG00230051565
 protein coding gene Chr14:62209051-62211464 (+)
NOD/ShiLtJ ENSMUSG00190045458
 protein coding gene Chr14:44812678-44815091 (+)
NZO/HlLtJ ENSMUSG00225045401
 protein coding gene Chr14:52499403-52501816 (+)
PWK/PhJ ENSLUMG00010045317
 protein coding gene Chr14:44269129-44271542 (+)
SPRET/EiJ ENSMSPG00010044518
 protein coding gene Chr14:47662505-47664906 (+)
WSB/EiJ ENSIUOG00005038272
 protein coding gene Chr14:44244625-44247038 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an increased succeptibility to parasitic infections which cause increased numbers of intestinal mucosal mast cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    6
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022227 Ensembl Gene Model | MGI Sequence Detail 2414 C57BL/6J ±  kb
    transcript ENSMUST00000022836 Ensembl | MGI Sequence Detail 1014 Not Applicable  
    polypeptide ENSMUSP00000022836 Ensembl | MGI Sequence Detail 246 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 9
      cDNA 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12143, MGD-MRK-12151, MGI:2145776
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:17707 Reynolds DS, et al., Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases. Proc Natl Acad Sci U S A. 1990 Apr;87(8):3230-4
    • Latest
      J:338310 Tauber M, et al., Landscape of mast cell populations across organs in mice and humans. J Exp Med. 2023 Oct 2;220(10)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory