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Mb Gene Detail
Summary
  • Symbol
    Mb
  • Name
    myoglobin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96922
    NCBI Gene: 17189
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76899687-76934868 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 36.36 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1278 from dbSNP Build 142
  • Strain Annotations
    14
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96922
 protein coding gene Chr15:76899687-76934870 (-)
129S1/SvImJ ENSMUSG00200053128
 protein coding gene Chr15:74013939-74024581 (-)
A/J ENSMUSG00195051021
 protein coding gene Chr15:73972594-73983238 (-)
AKR/J ENSMUSG00220049996
 protein coding gene Chr15:73999702-74010342 (-)
BALB/cJ ENSMUSG00180051803
 protein coding gene Chr15:73797732-73808384 (-)
C3H/HeJ ENSMUSG00175051722
 protein coding gene Chr15:74161119-74171767 (-)
C57BL/6NJ ENSMUSG00215049072
 protein coding gene Chr15:73905798-73916439 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019955
 protein coding gene Chr15:70951775-70985303 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210036679
 protein coding gene Chr15:73936344-73946988 (-)
DBA/2J ENSMUSG00185040712
 protein coding gene Chr15:73929366-73940004 (-)
FVB/NJ ENSMUSG00205049142
 protein coding gene Chr15:73665866-73676511 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230051658
 protein coding gene Chr15:77279034-77289678 (-)
NOD/ShiLtJ ENSMUSG00190053149
 protein coding gene Chr15:73925562-73936170 (-)
NZO/HlLtJ ENSMUSG00225049162
 protein coding gene Chr15:77599648-77610254 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MB, myoglobin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MB, myoglobin
  • Synonyms
    MYOSB, PVALB
  • Links
    NCBI Gene ID: 4151
    UniProt: P02144

  • Chr Location
    22q12.3; chr22:35606764-35637951 (-)  GRCh38
  • MGI Vertebrate Homology
    Mb stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: MB
  • Gene Tree
    Mb
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 3 alleles in 5 genetic backgrounds
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show increased cardiac capillary density, coronary flow, hemoglobin and hematocrit levels. Many mice homozygous for another null allele die of heart failure at midgestation; survivors show hypervascularity, altered NO metabolism, and hypoxia-induced cardiac dysfunction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    683
  • Tissues
    21
  • cDNA Data
    337
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17189 NCBI Gene Model | MGI Sequence Detail 35182 C57BL/6J ±  kb
    transcript NM_001164047 RefSeq | MGI Sequence Detail 1121 C57BL/6  
    polypeptide P04247 UniProt | EBI | MGI Sequence Detail 154 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 353
      Genomic 4
      cDNA 338
      Primer pair 10
      Other 1
      Antibodies 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12122, MGI:2145982
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 9
      Phenotypes 57
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:390213 Strehlau C, et al., Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity. Adv Sci (Weinh). 2026 Jun 25;:e76191
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory