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Mxd1 Gene Detail
Summary
  • Symbol
    Mxd1
  • Name
    MAX dimerization protein 1
  • Synonyms
    Mad, Mad1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96908
    NCBI Gene: 17119
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:86624026-86646099 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.75 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96908
 protein coding gene Chr6:86624024-86646143 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030980
 protein coding gene Chr6:87953655-87975400 (-)
A/J MGP_AJ_G0030946
 protein coding gene Chr6:84553265-84575034 (-)
AKR/J MGP_AKRJ_G0030877
 protein coding gene Chr6:87000510-87023472 (-)
BALB/cJ MGP_BALBcJ_G0030959
 protein coding gene Chr6:84564742-84586882 (-)
C3H/HeJ MGP_C3HHeJ_G0030751
 protein coding gene Chr6:97441087-97462856 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031416
 protein coding gene Chr6:90334972-90356803 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028600
 protein coding gene Chr6:82734789-82757206 (-)
CAST/EiJ MGP_CASTEiJ_G0030068
 protein coding gene Chr6:87072630-87094531 (-)
CBA/J MGP_CBAJ_G0030643
 protein coding gene Chr6:93886306-93908164 (-)
DBA/2J MGP_DBA2J_G0030799
 protein coding gene Chr6:83870755-83892506 (-)
FVB/NJ MGP_FVBNJ_G0030752
 protein coding gene Chr6:83054072-83075869 (-)
LP/J MGP_LPJ_G0030876
 protein coding gene Chr6:87984647-88006345 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030785
 protein coding gene Chr6:98003902-98026398 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031443
 protein coding gene Chr6:86839786-86861431 (-)
PWK/PhJ MGP_PWKPhJ_G0029783
 protein coding gene Chr6:82812569-82834346 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029611
 protein coding gene Chr6:85677742-85699289 (-)
WSB/EiJ MGP_WSBEiJ_G0030149
 protein coding gene Chr6:87306427-87328076 (-)



Homology
more
  • Human Ortholog
    MXD1, MAX dimerization protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MXD1, MAX dimerization protein 1
  • Synonyms
    BHLHC58, MAD, MAD1
  • Links
    NCBI Gene ID: 4084
    neXtProt AC: NX_Q05195
    UniProt: Q05195

  • Chr Location
    2p13.3; chr2:69897688-69942945 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered myelopoiesis, increased proliferative potential of bone marrow granulocytic precursors, increased sensitivity of myeloid cells to apoptosis-inducing stimuli, and inhibited cell cycle withdrawal during a late stage of granulocyte differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    917
  • Tissues
    199
  • cDNA Data
    21
  • Literature Summary
    13
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17119 NCBI Gene Model | MGI Sequence Detail 22074 C57BL/6J ±  kb
transcript NR_176938 RefSeq | MGI Sequence Detail 4685 ZRU/MplStud  
polypeptide P50538 UniProt | EBI | MGI Sequence Detail 227 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000010790 max dimerization protein 1
    (term hierarchy)
  • InterPro Domains
    IPR036638 Helix-loop-helix DNA-binding domain superfamily
    IPR040157 Max dimerization protein 1, basic Helix-Loop-Helix-zipper domain
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
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  • All nucleic 27
    cDNA 24
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-12100, MGI:2141648
References
more
  • Summaries
    All 60
    Developmental Gene Expression 13
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:19396 Ayer DE, et al., Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell. 1993 Jan 29;72(2):211-22
  • Latest
    J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory