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Kcnd1 Gene Detail
Summary
  • Symbol
    Kcnd1
  • Name
    potassium voltage-gated channel, Shal-related family, member 1
  • Synonyms
    1110037K09Rik, Kca2-1, Kv4.1, mShal1, Shal
  • Feature Type
    protein coding gene
  • IDs
    MGI:96671
    NCBI Gene: 16506
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7688528-7704519 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 3.53 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    340 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96671
 protein coding gene ChrX:7686907-7704519 (+)
129S1/SvImJ ENSMUSG00200030130
 protein coding gene ChrX:2389161-2405156 (+)
A/J ENSMUSG00195039515
 protein coding gene ChrX:2412129-2428125 (+)
AKR/J ENSMUSG00220031048
 protein coding gene ChrX:2399971-2416029 (+)
BALB/cJ ENSMUSG00180024627
 protein coding gene ChrX:2409827-2425828 (+)
C3H/HeJ ENSMUSG00175028444
 protein coding gene ChrX:2423800-2439797 (+)
C57BL/6NJ ENSMUSG00215039099
 protein coding gene ChrX:3087644-3103641 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032899
 protein coding gene ChrX:1968207-1985058 (+)
CAST/EiJ ENSTCUG00005030451
 protein coding gene ChrX:2358638-2374933 (+)
CBA/J ENSMUSG00210032820
 protein coding gene ChrX:2440683-2456678 (+)
DBA/2J ENSMUSG00185028660
 protein coding gene ChrX:9057805-9073804 (+)
FVB/NJ ENSMUSG00205029045
 protein coding gene ChrX:2434429-2450426 (+)
JF1/MsJ ENSUMUG00000034225
 protein coding gene ChrX:22944202-22960212 (+)
LP/J ENSMUSG00230029840
 protein coding gene ChrX:13578023-13594014 (+)
NOD/ShiLtJ ENSMUSG00190039247
 protein coding gene ChrX:2414825-2430879 (+)
NZO/HlLtJ ENSMUSG00225044993
 protein coding gene ChrX:18843539-18859534 (+)
PWK/PhJ ENSLUMG00010031857
 protein coding gene ChrX:2404548-2420567 (+)
SPRET/EiJ ENSMSPG00010020635
 protein coding gene ChrX:2442290-2458054 (+)
WSB/EiJ ENSIUOG00005031459
 protein coding gene ChrX:16096745-16112773 (-)



Homology
more
  • Human Ortholog
    KCND1, potassium voltage-gated channel subfamily D member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCND1, potassium voltage-gated channel subfamily D member 1
  • Synonyms
    KV4.1
  • Links
    NCBI Gene ID: 3750
    UniProt: Q9NSA2

  • Chr Location
    Xp11.23; chrX:48960982-48971866 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • Tissues
    18
  • cDNA Data
    19
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009731 Ensembl Gene Model | MGI Sequence Detail 15992 C57BL/6J ±  kb
    transcript ENSMUST00000009875 Ensembl | MGI Sequence Detail 5287 Not Applicable  
    polypeptide ENSMUSP00000009875 Ensembl | MGI Sequence Detail 651 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000000784 voltage-gated potassium channel KCND1
      (term hierarchy)
    • InterPro Domains
      IPR000210 BTB/POZ domain
      IPR005821 Ion transport domain
      IPR003131 Potassium channel tetramerisation-type BTB domain
      IPR003968 Potassium channel, voltage dependent, Kv
      IPR003975 Potassium channel, voltage dependent, Kv4
      IPR004054 Potassium channel, voltage dependent, Kv4.1
      IPR024587 Potassium channel, voltage dependent, Kv4, C-terminal
      IPR021645 Shal-type voltage-gated potassium channels, N-terminal
      IPR011333 SKP1/BTB/POZ domain superfamily
      IPR027359 Voltage-dependent channel domain superfamily
      IPR028325 Voltage-gated potassium channel
    • GlyGen
      Q03719 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 5
      cDNA 19
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11557, MGD-MRK-11575, MGD-MRK-14398, MGI:1915999
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 9
    • Earliest
      J:11182 Pak MD, et al., mShal, a subfamily of A-type K+ channel cloned from mammalian brain. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4386-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory