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Kcnc3 Gene Detail
Summary
  • Symbol
    Kcnc3
  • Name
    potassium voltage gated channel, Shaw-related subfamily, member 3
  • Synonyms
    Kcr2-3, KShIIID, Kv3.3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96669
    NCBI Gene: 16504
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44240088-44254178 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.85 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    282 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96669
 protein coding gene Chr7:44236405-44254178 (+)
129S1/SvImJ ENSMUSG00200024668
 protein coding gene Chr7:31832855-31846952 (+)
A/J ENSMUSG00195046989
 protein coding gene Chr7:35860742-35874833 (+)
AKR/J ENSMUSG00220007474
 protein coding gene Chr7:30165793-30179888 (+)
BALB/cJ ENSMUSG00180035547
 protein coding gene Chr7:32736127-32750219 (+)
C3H/HeJ ENSMUSG00175034956
 protein coding gene Chr7:33268781-33282878 (+)
C57BL/6NJ ENSMUSG00215043391
 protein coding gene Chr7:32529851-32543941 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029668
 protein coding gene Chr7:46532120-46546090 (+)
CAST/EiJ ENSTCUG00005045982
 protein coding gene Chr7:36245688-36259798 (+)
CBA/J ENSMUSG00210047143
 protein coding gene Chr7:33640174-33654269 (+)
DBA/2J ENSMUSG00185042690
 protein coding gene Chr7:37512514-37526608 (+)
FVB/NJ ENSMUSG00205035749
 protein coding gene Chr7:33185379-33199476 (+)
JF1/MsJ ENSUMUG00000014997
 protein coding gene Chr7:41999776-42013874 (+)
LP/J ENSMUSG00230050314
 protein coding gene Chr7:42935550-42949634 (+)
NOD/ShiLtJ ENSMUSG00190025391
 protein coding gene Chr7:33513157-33527253 (+)
NZO/HlLtJ ENSMUSG00225016181
 protein coding gene Chr7:41146328-41160419 (+)
PWK/PhJ ENSLUMG00010038048
 protein coding gene Chr7:32468881-32482963 (+)
SPRET/EiJ ENSMSPG00010040037
 protein coding gene Chr7:32249988-32264004 (+)
WSB/EiJ ENSIUOG00005024060
 protein coding gene Chr7:34058096-34072187 (+)



Homology
more
  • Human Ortholog
    KCNC3, potassium voltage-gated channel subfamily C member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNC3, potassium voltage-gated channel subfamily C member 3
  • Synonyms
    KSHIIID, KV3.3, SCA13
  • Links
    NCBI Gene ID: 3748
    UniProt: Q14003

  • Chr Location
    19q13.33; chr19:50311937-50333536 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KCNC3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozgous null mice show no overt phenotype, though mutation of this locus in conjunction with mutations in another potassium channel results in alcohol hypersensitivty, increased locomotion, and spontaneous myoclonus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    662
  • Tissues
    19
  • cDNA Data
    18
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062785 Ensembl Gene Model | MGI Sequence Detail 14091 C57BL/6J ±  kb
    transcript ENSMUST00000107906 Ensembl | MGI Sequence Detail 5062 Not Applicable  
    polypeptide ENSMUSP00000103539 Ensembl | MGI Sequence Detail 770 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000009254 voltage-gated potassium channel KCNC3
      (term hierarchy)
    • InterPro Domains
      IPR000210 BTB/POZ domain
      IPR005821 Ion transport domain
      IPR003131 Potassium channel tetramerisation-type BTB domain
      IPR003968 Potassium channel, voltage dependent, Kv
      IPR003974 Potassium channel, voltage dependent, Kv3
      IPR005404 Potassium channel, voltage dependent, Kv3.3
      IPR011333 SKP1/BTB/POZ domain superfamily
      IPR027359 Voltage-dependent channel domain superfamily
      IPR028325 Voltage-gated potassium channel
    • GlyGen
      Q63959 8 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 2
      cDNA 20
      Primer pair 1
      Other 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11573, MGD-MRK-11581
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 4
      Gene Ontology 16
      Phenotypes 25
    • Earliest
      J:2312 Ghanshani S, et al., Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 1992 Feb;12(2):190-6
    • Latest
      J:386370 Ma D, et al., Proper localization of the SCA13-linked K(+) channel in Purkinje neurons requires a microtubule-stabilizing protein. Neurobiol Dis. 2026 Apr 30;225:107429
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory