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Kcnc2 Gene Detail
Summary
  • Symbol
    Kcnc2
  • Name
    potassium voltage gated channel, Shaw-related subfamily, member 2
  • Synonyms
    KShIIIA, Kv3.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96668
    NCBI Gene: 268345
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:112107026-112302929 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 60.30 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5869 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96668
 protein coding gene Chr10:112105803-112302929 (+)
129S1/SvImJ ENSMUSG00200010170
 protein coding gene Chr10:108526241-108721955 (+)
A/J ENSMUSG00195008178
 protein coding gene Chr10:108941761-109137690 (+)
AKR/J ENSMUSG00220024522
 protein coding gene Chr10:108521425-108717348 (+)
BALB/cJ ENSMUSG00180023435
 protein coding gene Chr10:108961218-109156931 (+)
C3H/HeJ ENSMUSG00175014894
 protein coding gene Chr10:108889559-109085471 (+)
C57BL/6NJ ENSMUSG00215010071
 protein coding gene Chr10:108612580-108808502 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015805
 protein coding gene Chr10:105192613-105373239 (+)
CAST/EiJ ENSTCUG00005011304
 protein coding gene Chr10:107967993-108137690 (+)
CBA/J ENSMUSG00210011473
 protein coding gene Chr10:108760878-108956780 (+)
DBA/2J ENSMUSG00185024134
 protein coding gene Chr10:108888221-109071723 (+)
FVB/NJ no annotation
JF1/MsJ ENSUMUG00000007579
 protein coding gene Chr10:110204922-110400501 (+)
LP/J ENSMUSG00230011747
 protein coding gene Chr10:110835430-111031335 (+)
NOD/ShiLtJ ENSMUSG00190019439
 protein coding gene Chr10:108988660-109184578 (+)
NZO/HlLtJ ENSMUSG00225016550
 protein coding gene Chr10:115089795-115285690 (+)
PWK/PhJ ENSLUMG00010013802
 protein coding gene Chr10:108583537-108772563 (+)
SPRET/EiJ ENSMSPG00010005459
 protein coding gene Chr10:110448018-110625386 (+)
WSB/EiJ ENSIUOG00005010272
 protein coding gene Chr10:108643327-108839961 (+)



Homology
more
  • Human Ortholog
    KCNC2, potassium voltage-gated channel subfamily C member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNC2, potassium voltage-gated channel subfamily C member 2
  • Synonyms
    DEE103, KV3.2
  • Links
    NCBI Gene ID: 3747
    UniProt: Q96PR1

  • Chr Location
    12q21.1; chr12:75040077-75209839 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KCNC2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display impaired fast spiking in cortical interneurons, distorted cortical rhythmic activity, enhanced susceptibility to seizures, increased anxiety in the open field, and abnormal sleep patterns.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    99
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    703
  • Tissues
    36
  • cDNA Data
    12
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035681 Ensembl Gene Model | MGI Sequence Detail 195904 C57BL/6J ±  kb
transcript ENSMUST00000092175 Ensembl | MGI Sequence Detail 5046 Not Applicable  
polypeptide ENSMUSP00000089814 Ensembl | MGI Sequence Detail 642 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 13
    Primer pair 2
    Other 1
    Antibodies 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-11572, MGI:2143797
References
more
  • Summaries
    All 72
    Developmental Gene Expression 9
    Gene Ontology 18
    Phenotypes 22
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory