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Itgb5 Gene Detail
Summary
  • Symbol
    Itgb5
  • Name
    integrin beta 5
  • Synonyms
    [b]-5, [b]5, [b]5A, [b]5B, beta-5, beta5, ESTM23
  • Feature Type
    protein coding gene
  • IDs
    MGI:96614
    NCBI Gene: 16419
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:33650035-33769708 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 24.22 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3554 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96614
 protein coding gene Chr16:33650021-33769708 (+)
129S1/SvImJ ENSMUSG00200026240
 protein coding gene Chr16:30677472-30797155 (+)
A/J ENSMUSG00195010694
 protein coding gene Chr16:30215865-30335559 (+)
AKR/J ENSMUSG00220026920
 protein coding gene Chr16:30501799-30621459 (+)
BALB/cJ ENSMUSG00180012923
 protein coding gene Chr16:30431714-30551419 (+)
C3H/HeJ ENSMUSG00175028875
 protein coding gene Chr16:30573782-30693476 (+)
C57BL/6NJ ENSMUSG00215012127
 protein coding gene Chr16:30456632-30576380 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020693
 protein coding gene Chr16:30863868-30981832 (+)
CAST/EiJ ENSTCUG00005030388
 protein coding gene Chr16:30845811-30971214 (+)
CBA/J ENSMUSG00210027563
 protein coding gene Chr16:30615688-30735370 (+)
DBA/2J ENSMUSG00185023563
 protein coding gene Chr16:30531241-30650916 (+)
FVB/NJ ENSMUSG00205017283
 protein coding gene Chr16:30546952-30666633 (+)
JF1/MsJ ENSUMUG00000032583
 protein coding gene Chr16:30746720-30862867 (+)
LP/J ENSMUSG00230028912
 protein coding gene Chr16:33099814-33219556 (+)
NOD/ShiLtJ ENSMUSG00190020156
 protein coding gene Chr16:30723801-30843472 (+)
NZO/HlLtJ ENSMUSG00225037715
 protein coding gene Chr16:36342755-36462421 (+)
PWK/PhJ ENSLUMG00010026264
 protein coding gene Chr16:30642573-30759622 (+)
SPRET/EiJ ENSMSPG00010016055
 protein coding gene Chr16:30557340-30674422 (+)
WSB/EiJ ENSIUOG00005025673
 protein coding gene Chr16:30704385-30824132 (+)



Homology
more
  • Human Ortholog
    ITGB5, integrin subunit beta 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGB5, integrin subunit beta 5
  • Links
    NCBI Gene ID: 3693
    UniProt: P18084

  • Chr Location
    3q21.2; chr3:124761948-124901418 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation do not appear to differ from normal in respect to development, reproduction, adenovirus infection, or wound healing. Mutant keratinocytes do show reduced migration on, and adhesion to, vitronectin in vitro.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    833
  • Tissues
    199
  • cDNA Data
    17
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022817 Ensembl Gene Model | MGI Sequence Detail 119674 C57BL/6J ±  kb
    transcript ENSMUST00000069345 Ensembl | MGI Sequence Detail 3056 Not Applicable  
    polypeptide ENSMUSP00000069416 Ensembl | MGI Sequence Detail 816 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000009141 integrin beta-5
      (term hierarchy)
    • InterPro Domains
      IPR013111 Epidermal growth factor-like domain, extracellular
      IPR040622 Integrin beta, epidermal growth factor-like domain 1
      IPR057073 Integrin beta, epidermal growth factor-like domain 2
      IPR033760 Integrin beta N-terminal
      IPR015812 Integrin beta subunit
      IPR014836 Integrin beta subunit, cytoplasmic domain
      IPR012896 Integrin beta subunit, tail
      IPR002369 Integrin beta subunit, VWA domain
      IPR036349 Integrin beta tail domain superfamily
      IPR032695 Integrin domain superfamily
      IPR016201 PSI domain
      IPR036465 von Willebrand factor A-like domain superfamily
      IPR002035 von Willebrand factor, type A
    • GlyGen
      O70309 8 sites, 5 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 18
      Primer pair 3
      Other 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11493, MGI:1201382, MGI:2146516
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 19
      Gene Ontology 13
      Phenotypes 38
    • Earliest
      J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
    • Latest
      J:374792 Estep JA, et al., Functional role for Cas cytoplasmic adaptor proteins during cortical axon pathfinding. PLoS Genet. 2025 Nov;21(11):e1011941
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory