About   Help   FAQ
Igh-J Complex/Cluster/Region Detail
Summary
  • Symbol
    Igh-J
  • Name
    immunoglobulin heavy chain, joining region
  • Synonyms
    Jh
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:96461
    NCBI Gene: 16033
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 12, Syntenic
  • Mapping Data
    1 experiment
Strain
Comparison
more
Human Diseases
more
  • Diseases
    1 with Igh-J mouse models

Human Disease Mouse Models
      
IDs
 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 11 alleles in 9 genetic backgrounds
    62 phenotypes from multigenic genotypes
    1 images
    346 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeting alleles exhibit altered immune system morphology and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1
  • Tissues
    1
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    Sequences &
    Gene Models
    less
    • All Sequences
      15
    • UniProt
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic X63164 GenBank | ENA | DDBJ | MGI Sequence Detail 1342 A/J ±  kb
    polypeptide P01808 UniProt | EBI | MGI Sequence Detail 119 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    Molecular
    Reagents
    less
    • All nucleic 325
      Genomic 178
      cDNA 144
      Primer pair 1
      Other 2
    Other
    Accession IDs
    less
    MGD-MRK-11258
    References
    more
    • Summaries
      All 458
      Developmental Gene Expression 1
      Diseases 4
      Gene Ontology 3
      Phenotypes 346
    • Earliest
      J:6108 Early PW, et al., Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions. Proc Natl Acad Sci U S A. 1979 Feb;76(2):857-61
    • Latest
      J:338851 Sagan SA, et al., T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2306572120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory