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Igfbp6 Gene Detail
Summary
  • Symbol
    Igfbp6
  • Name
    insulin-like growth factor binding protein 6
  • Synonyms
    IGFBP-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:96441
    NCBI Gene: 16012
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102052797-102057946 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 57.32 cM
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96441
 protein coding gene Chr15:102052621-102057947 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022400
 protein coding gene Chr15:104295490-104300775 (+)
A/J MGP_AJ_G0022362
 protein coding gene Chr15:100204150-100208923 (+)
AKR/J MGP_AKRJ_G0022337
 protein coding gene Chr15:103234166-103239285 (+)
BALB/cJ MGP_BALBcJ_G0022366
 protein coding gene Chr15:100247090-100252206 (+)
C3H/HeJ MGP_C3HHeJ_G0022133
 protein coding gene Chr15:103311006-103315781 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022815
 protein coding gene Chr15:108176395-108181495 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020338
 protein coding gene Chr15:95979201-95984001 (+)
CAST/EiJ MGP_CASTEiJ_G0021659
 protein coding gene Chr15:104166724-104172450 (+)
CBA/J MGP_CBAJ_G0022102
 protein coding gene Chr15:111957471-111962360 (+)
DBA/2J MGP_DBA2J_G0022233
 protein coding gene Chr15:99491254-99496375 (+)
FVB/NJ MGP_FVBNJ_G0022209
 protein coding gene Chr15:98548535-98556739 (+)
LP/J MGP_LPJ_G0022302
 protein coding gene Chr15:104454768-104463377 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022231
 protein coding gene Chr15:115549463-115554595 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022827
 protein coding gene Chr15:103256625-103261762 (+)
PWK/PhJ MGP_PWKPhJ_G0021399
 protein coding gene Chr15:99639921-99645564 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021231
 protein coding gene Chr15:103101709-103106478 (+)
WSB/EiJ MGP_WSBEiJ_G0021709
 protein coding gene Chr15:103884703-103891704 (+)



Homology
more
  • Human Ortholog
    IGFBP6, insulin like growth factor binding protein 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGFBP6, insulin like growth factor binding protein 6
  • Synonyms
    IBP6
  • Links
    NCBI Gene ID: 3489
    neXtProt AC: NX_P24592
    UniProt: P24592

  • Chr Location
    12q13.13; chr12:53097436-53102345 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IGFBP6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    775
  • Tissues
    53
  • cDNA Data
    42
  • Literature Summary
    23
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023046 Ensembl Gene Model | MGI Sequence Detail 5150 C57BL/6J ±  kb
transcript ENSMUST00000023807 Ensembl | MGI Sequence Detail 1112 Not Applicable  
polypeptide ENSMUSP00000023807 Ensembl | MGI Sequence Detail 238 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008952 insulin-like growth factor-binding protein 6
    (term hierarchy)
  • InterPro Domains
    IPR009030 Growth factor receptor cysteine-rich domain superfamily
    IPR022326 Insulin-like growth factor-binding protein 6
    IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
    IPR000867 Insulin-like growth factor-binding protein, IGFBP
    IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
    IPR000716 Thyroglobulin type-1
    IPR036857 Thyroglobulin type-1 superfamily
Molecular
Reagents
less
  • All nucleic 45
    cDNA 42
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11238
References
more
  • Summaries
    All 82
    Developmental Gene Expression 23
    Diseases 1
    Gene Ontology 7
    Phenotypes 28
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory