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Ica1 Gene Detail
Summary
  • Symbol
    Ica1
  • Name
    islet cell autoantigen 1
  • Synonyms
    69kDa, ICA69
  • Feature Type
    protein coding gene
  • IDs
    MGI:96391
    NCBI Gene: 15893
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:8630527-8778488 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 4.38 cM, cytoband A1-A2
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1204 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96391
 protein coding gene Chr6:8630527-8778531 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030452
 protein coding gene Chr6:5549236-5700622 (-)
A/J MGP_AJ_G0030425
 protein coding gene Chr6:5370775-5510527 (-)
AKR/J MGP_AKRJ_G0030352
 protein coding gene Chr6:5566792-5715059 (-)
BALB/cJ MGP_BALBcJ_G0030434
 protein coding gene Chr6:5350786-5492844 (-)
C3H/HeJ MGP_C3HHeJ_G0030148
 protein coding gene Chr6:5454970-5603926 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030889
 protein coding gene Chr6:5730895-5880295 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028100
 protein coding gene Chr6:4865987-5002906 (-)
CAST/EiJ MGP_CASTEiJ_G0029549
 protein coding gene Chr6:5441182-5591598 (-)
CBA/J MGP_CBAJ_G0030126
 protein coding gene Chr6:5874708-6033907 (-)
DBA/2J MGP_DBA2J_G0030270
 protein coding gene Chr6:5302559-5442664 (-)
FVB/NJ MGP_FVBNJ_G0030224
 protein coding gene Chr6:5271165-5417395 (-)
LP/J MGP_LPJ_G0030357
 protein coding gene Chr6:5529551-5679904 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030260
 protein coding gene Chr6:5973662-6127169 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030919
 protein coding gene Chr6:5439020-5585907 (-)
PWK/PhJ MGP_PWKPhJ_G0029264
 protein coding gene Chr6:5194249-5337174 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029100
 protein coding gene Chr6:5490184-5638726 (-)
WSB/EiJ MGP_WSBEiJ_G0029626
 protein coding gene Chr6:5433468-5584589 (-)



Homology
more
  • Human Ortholog
    ICA1, islet cell autoantigen 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ICA1, islet cell autoantigen 1
  • Synonyms
    ICA69, ICAp69
  • Links
    NCBI Gene ID: 3382
    neXtProt AC: NX_Q05084
    UniProt: Q05084

  • Chr Location
    7p21.3; chr7:8113184-8262687 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ICA1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in diabetes and spontaneous lethality at 4-5 months of age on a NOD background, however mice on a 129/Sv background are normal. Onset of diabetes starts 4 weeks later than wild-type NOD mice and mutants are resistant to cyclophospamide-accelerated diabetes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1001
  • Tissues
    70
  • cDNA Data
    49
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062995 Ensembl Gene Model | MGI Sequence Detail 147962 C57BL/6J ±  kb
    transcript ENSMUST00000115520 Ensembl | MGI Sequence Detail 1876 Not Applicable  
    polypeptide ENSMUSP00000111182 Ensembl | MGI Sequence Detail 478 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      Genomic 11
      cDNA 51
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11145
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:13253 Pietropaolo M, et al., Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen. J Clin Invest. 1993 Jul;92(1):359-71
    • Latest
      J:346332 Chiu SL, et al., ICA69 regulates activity-dependent synaptic strengthening and learning and memory. Front Mol Neurosci. 2023;16:1171432
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory