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Htr1d Gene Detail
Summary
  • Symbol
    Htr1d
  • Name
    5-hydroxytryptamine (serotonin) receptor 1D
  • Synonyms
    Gpcr14, Htr1db
  • Feature Type
    protein coding gene
  • IDs
    MGI:96276
    NCBI Gene: 15552
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:136150835-136171709 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 68.74 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    237 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96276
 protein coding gene Chr4:136150829-136176284 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028966
 protein coding gene Chr4:138988916-139013141 (+)
A/J MGP_AJ_G0028925
 protein coding gene Chr4:133058851-133080428 (+)
AKR/J MGP_AKRJ_G0028877
 protein coding gene Chr4:136906111-136927218 (+)
BALB/cJ MGP_BALBcJ_G0028949
 protein coding gene Chr4:133720182-133743115 (+)
C3H/HeJ MGP_C3HHeJ_G0028663
 protein coding gene Chr4:137187796-137213588 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029390
 protein coding gene Chr4:143961521-143982446 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026661
 protein coding gene Chr4:126094482-126116309 (+)
CAST/EiJ MGP_CASTEiJ_G0028095
 protein coding gene Chr4:135341441-135363515 (+)
CBA/J MGP_CBAJ_G0028628
 protein coding gene Chr4:147867399-147924793 (+)
DBA/2J MGP_DBA2J_G0028777
 protein coding gene Chr4:133474398-133495177 (+)
FVB/NJ MGP_FVBNJ_G0028744
 protein coding gene Chr4:132425441-132446427 (+)
LP/J MGP_LPJ_G0028876
 protein coding gene Chr4:139072843-139099459 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028770
 protein coding gene Chr4:152080257-152100929 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029428
 protein coding gene Chr4:137382026-137406635 (+)
PWK/PhJ MGP_PWKPhJ_G0027815
 protein coding gene Chr4:130254915-130278641 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027641
 protein coding gene Chr4:133186885-133207235 (+)
WSB/EiJ MGP_WSBEiJ_G0028173
 protein coding gene Chr4:137534901-137559168 (+)



Homology
more
  • Human Ortholog
    HTR1D, 5-hydroxytryptamine receptor 1D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTR1D, 5-hydroxytryptamine receptor 1D
  • Synonyms
    5-HT1D, HT1DA, HTR1DA, HTRL, RDC4
  • Links
    NCBI Gene ID: 3352
    neXtProt AC: NX_P28221
    UniProt: P28221

  • Chr Location
    1p36.12; chr1:23191895-23217502 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    998
  • Tissues
    150
  • cDNA Data
    9
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000070687 Ensembl Gene Model | MGI Sequence Detail 20875 C57BL/6J ±  kb
    transcript ENSMUST00000088677 Ensembl | MGI Sequence Detail 2904 Not Applicable  
    polypeptide ENSMUSP00000086052 Ensembl | MGI Sequence Detail 374 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 4
      cDNA 10
      Primer pair 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11002, MGD-MRK-11004, MGD-MRK-16348, MGI:2140395, MGI:96278, MGI:99568
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 12
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:43 Maroteaux L, et al., Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3020-4
    • Latest
      J:325980 Zhu P, et al., 5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis. Neuron. 2022 May 7;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory