About   Help   FAQ
Hspa2 Gene Detail
Summary
  • Symbol
    Hspa2
  • Name
    heat shock protein 2
  • Synonyms
    70kDa, Hsp70-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96243
    NCBI Gene: 15512
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:76450950-76453712 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 33.73 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96243
 protein coding gene Chr12:76450688-76453712 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019858
 protein coding gene Chr12:76515818-76518576 (+)
A/J MGP_AJ_G0019816
 protein coding gene Chr12:73610768-73613526 (+)
AKR/J MGP_AKRJ_G0019791
 protein coding gene Chr12:75837962-75840706 (+)
BALB/cJ MGP_BALBcJ_G0019795
 protein coding gene Chr12:74084866-74087624 (+)
C3H/HeJ MGP_C3HHeJ_G0019601
 protein coding gene Chr12:76297170-76299928 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020247
 protein coding gene Chr12:78861060-78863818 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017865
 protein coding gene Chr12:70941868-70944620 (+)
CAST/EiJ MGP_CASTEiJ_G0019152
 protein coding gene Chr12:71108168-71110916 (+)
CBA/J MGP_CBAJ_G0019571
 protein coding gene Chr12:81909409-81912167 (+)
DBA/2J MGP_DBA2J_G0019687
 protein coding gene Chr12:73459663-73462407 (+)
FVB/NJ MGP_FVBNJ_G0019674
 protein coding gene Chr12:72302656-72305407 (+)
LP/J MGP_LPJ_G0019759
 protein coding gene Chr12:76491834-76494592 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019713
 protein coding gene Chr12:84934830-84937588 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020283
 protein coding gene Chr12:75311010-75313768 (+)
PWK/PhJ MGP_PWKPhJ_G0018918
 protein coding gene Chr12:67831392-67834195 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018712
 protein coding gene Chr12:69830357-69833114 (+)
WSB/EiJ MGP_WSBEiJ_G0019204
 protein coding gene Chr12:75931070-75933814 (+)



Homology
more
  • Human Ortholog
    HSPA2, heat shock protein family A (Hsp70) member 2
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPA2, heat shock protein family A (Hsp70) member 2
  • Synonyms
    HSP70-2, HSP70-3
  • Links
    NCBI Gene ID: 3306
    neXtProt AC: NX_P54652
    UniProt: P54652

  • Chr Location
    14q23.3; chr14:64535905-64546173 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit male sterility associated with lack of postmeiotic germ cells and markedly increased frequency of spermatocyte apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    20
  • cDNA Data
    35
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059970 Ensembl Gene Model | MGI Sequence Detail 2763 C57BL/6J ±  kb
    transcript ENSMUST00000080449 Ensembl | MGI Sequence Detail 2524 Not Applicable  
    polypeptide ENSMUSP00000079306 Ensembl | MGI Sequence Detail 633 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000008807 heat shock-related 70 kDa protein 2
      (term hierarchy)
    • InterPro Domains
      IPR043129 ATPase, nucleotide binding domain
      IPR018181 Heat shock protein 70, conserved site
      IPR013126 Heat shock protein 70 family
      IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
      IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 12
      cDNA 35
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10959, MGD-MRK-19433
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 10
      Gene Ontology 22
      Phenotypes 12
    • Earliest
      J:9294 Zakeri ZF, et al., Identification and sequence analysis of a new member of the mouse HSP70 gene family and characterization of its unique cellular and developmental pattern of expression in the male germ line. Mol Cell Biol. 1988 Jul;8(7):2925-32
    • Latest
      J:344312 Liu H, et al., Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development. iScience. 2024 Jan 19;27(1):108722
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory