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Hsd3b4 Gene Detail
Summary
  • Symbol
    Hsd3b4
  • Name
    hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4
  • Synonyms
    3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase
  • Feature Type
    protein coding gene
  • IDs
    MGI:96236
    NCBI Gene: 15495
  • Member of
    Hsd3b cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr3:98406387-98417830 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 42.79 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • Strain Annotations
    10
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96236
 protein coding gene Chr3:98406387-98417895 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027655
 protein coding gene Chr3:99448059-99460927 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0027627
 protein coding gene Chr3:96175983-96187441 (-)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0027444
 protein coding gene Chr3:93735744-93749808 (-)
LP/J MGP_LPJ_G0027582
 protein coding gene Chr3:100965392-100981676 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027470
 protein coding gene Chr3:112833013-112858643 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035646
 protein coding gene Chr9:93239287-93243245 (+)
PWK/PhJ MGP_PWKPhJ_G0026538
 protein coding gene Chr3:95558291-95576828 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026361
 protein coding gene Chr3:96562018-96574228 (-)
WSB/EiJ MGP_WSBEiJ_G0026892
 protein coding gene Chr3:98903608-98904475 (-)



Homology
more
  • Human Ortholog
    HSD3B1, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSD3B1, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
  • Synonyms
    3BETAHSD, HSD3B, HSDB3, HSDB3A, SDR11E1
  • Links
    NCBI Gene ID: 3283
    neXtProt AC: NX_P14060
    UniProt: P14060

  • Chr Location
    1p12; chr1:119507198-119515058 (+)  GRCh38
  • Human Ortholog
    HSD3B2, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
  • Synonyms
    HSD3B, HSDB, SDR11E2
  • Links
    NCBI Gene ID: 3284
    neXtProt AC: NX_P26439
    UniProt: P26439

  • Chr Location
    1p12; chr1:119414931-119423035 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human HSD3B1,HSD3B2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Hsd3b4
  • Find Mice (IMSR)
    0 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    872
  • Tissues
    112
  • cDNA Data
    12
  • Literature Summary
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000095143 Ensembl Gene Model | MGI Sequence Detail 11444 C57BL/6J ±  kb
transcript ENSMUST00000179429 Ensembl | MGI Sequence Detail 1575 Not Applicable  
polypeptide ENSMUSP00000136588 Ensembl | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    Genomic 2
    cDNA 13
    Primer pair 4
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10949
References
more
  • Summaries
    All 44
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 10
    Phenotypes 4
  • Earliest
    J:4363 Bain PA, et al., The genes encoding gonadal and nongonadal forms of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase are closely linked on mouse chromosome 3. Genomics. 1993 Apr;16(1):219-23
  • Latest
    J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory