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Hsd3b1 Gene Detail
Summary
  • Symbol
    Hsd3b1
  • Name
    hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
  • Synonyms
    D3Ertd383e
  • Feature Type
    protein coding gene
  • IDs
    MGI:96233
    NCBI Gene: 15492
  • Member of
    Hsd3b cluster
  • Alliance
    genome feature page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:98759510-98767110 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 42.89 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96233
 protein coding gene Chr3:98749672-98767110 (-)
129S1/SvImJ ENSMUSG00200043888
 protein coding gene Chr3:95369988-95377586 (-)
A/J ENSMUSG00195047813
 protein coding gene Chr3:95736880-95744480 (-)
AKR/J ENSMUSG00220038144
 protein coding gene Chr3:94099862-94107462 (-)
BALB/cJ ENSMUSG00180035039
 protein coding gene Chr3:95679266-95686866 (-)
C3H/HeJ ENSMUSG00175022457
 protein coding gene Chr3:95295159-95302759 (-)
C57BL/6NJ ENSMUSG00215014303
 protein coding gene Chr3:96011606-96019206 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025416
 protein coding gene Chr3:93048947-93056380 (-)
CAST/EiJ ENSTCUG00005018044
 protein coding gene Chr3:95994881-96002492 (-)
CBA/J ENSMUSG00210051186
 protein coding gene Chr3:95848040-95855640 (-)
DBA/2J ENSMUSG00185038292
 protein coding gene Chr3:96328352-96335950 (-)
FVB/NJ ENSMUSG00205020508
 protein coding gene Chr3:94944221-94951819 (-)
JF1/MsJ ENSUMUG00000042595
 protein coding gene Chr3:95056905-95064517 (-)
LP/J ENSMUSG00230044151
 protein coding gene Chr3:98298296-98305894 (-)
NOD/ShiLtJ ENSMUSG00190025414
 protein coding gene Chr3:96494497-96502102 (-)
NZO/HlLtJ ENSMUSG00225012216
 protein coding gene Chr3:100704722-100712301 (-)
PWK/PhJ ENSLUMG00010027685
 protein coding gene Chr3:95162462-95170073 (-)
SPRET/EiJ ENSMSPG00010037526
 protein coding gene Chr3:95324268-95330442 (-)
WSB/EiJ ENSIUOG00005026621
 protein coding gene Chr3:95851935-95859540 (-)



Homology
more
  • Human Ortholog
    HSD3B1, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSD3B1, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
  • Synonyms
    3BETAHSD, HSD3B, HSDB3, HSDB3A, SDR11E1
  • Links
    NCBI Gene ID: 3283
    UniProt: P14060

  • Chr Location
    1p12; chr1:119507198-119515058 (+)  GRCh38
  • Human Ortholog
    HSD3B2, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
  • Synonyms
    HSD3B, HSDB, SDR11E2
  • Links
    NCBI Gene ID: 3284
    UniProt: P26439

  • Chr Location
    1p12; chr1:119413725-119423035 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human HSD3B1,HSD3B2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1050
  • Tissues
    193
  • cDNA Data
    47
  • Literature Summary
    74
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027871 Ensembl Gene Model | MGI Sequence Detail 7601 C57BL/6J ±  kb
transcript ENSMUST00000029465 Ensembl | MGI Sequence Detail 1663 Not Applicable  
polypeptide ENSMUSP00000029465 Ensembl | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    Genomic 2
    cDNA 50
    Primer pair 13
    Antibodies 10

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10946, MGI:1196249
References
more
  • Summaries
    All 125
    Developmental Gene Expression 74
    Diseases 1
    Gene Ontology 16
    Phenotypes 5
  • Earliest
    J:29466 Bain PA, et al., Multiple forms of mouse 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase and differential expression in gonads, adrenal glands, liver, and kidneys of both sexes. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8870-4
  • Latest
    J:385762 Li SY, et al., Platelet-derived growth factor receptor alpha regulates fetal testis differentiation via an ERK-CREB axis. Proc Natl Acad Sci U S A. 2026 Jan 27;123(4):e2515138123
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory