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Hoxd12 Gene Detail
Summary
  • Symbol
    Hoxd12
  • Name
    homeobox D12
  • Synonyms
    Hox-4.7, Hox-5.6
  • Feature Type
    protein coding gene
  • IDs
    MGI:96204
    NCBI Gene: 15432
  • Member of
    Hoxd cluster
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:74505357-74508049 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 44.13 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96204
 protein coding gene Chr2:74505357-74508049 (+)
129S1/SvImJ ENSMUSG00200003088
 protein coding gene Chr2:71553993-71556691 (+)
A/J ENSMUSG00195018891
 protein coding gene Chr2:71700681-71703379 (+)
AKR/J ENSMUSG00220002331
 protein coding gene Chr2:71665327-71668025 (+)
BALB/cJ ENSMUSG00180006792
 protein coding gene Chr2:71654351-71657049 (+)
C3H/HeJ ENSMUSG00175010237
 protein coding gene Chr2:71780238-71782929 (+)
C57BL/6NJ ENSMUSG00215020476
 protein coding gene Chr2:71617186-71619879 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023668
 protein coding gene Chr2:69479335-69482048 (+)
CAST/EiJ ENSTCUG00005027425
 protein coding gene Chr2:71094051-71096744 (+)
CBA/J ENSMUSG00210002080
 protein coding gene Chr2:71822889-71825579 (+)
DBA/2J ENSMUSG00185011432
 protein coding gene Chr2:71658738-71661429 (+)
FVB/NJ ENSMUSG00205011905
 protein coding gene Chr2:71110719-71113417 (+)
JF1/MsJ ENSUMUG00000023288
 protein coding gene Chr2:71335820-71338514 (+)
LP/J ENSMUSG00230023676
 protein coding gene Chr2:73453583-73456280 (+)
NOD/ShiLtJ ENSMUSG00190010700
 protein coding gene Chr2:71733451-71736148 (+)
NZO/HlLtJ ENSMUSG00225014240
 protein coding gene Chr2:81217650-81220341 (+)
PWK/PhJ ENSLUMG00010030226
 protein coding gene Chr2:71574210-71576902 (+)
SPRET/EiJ ENSMSPG00010019503
 protein coding gene Chr2:72974219-72976909 (+)
WSB/EiJ ENSIUOG00005010889
 protein coding gene Chr2:71776765-71779456 (+)



Homology
more
  • Human Ortholog
    HOXD12, homeobox D12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXD12, homeobox D12
  • Synonyms
    HOX4H
  • Links
    NCBI Gene ID: 3238
    UniProt: P35452

  • Chr Location
    2q31.1; chr2:176099795-176102489 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HOXD12 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit minor forelimb defects affecting carpals, metacarpals, and phalanges, and alterations of smooth muscle layers of the rectum resulting in malformation of the internal anal sphincter.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1099
  • Tissues
    271
  • cDNA Data
    12
  • Literature Summary
    146
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15432 NCBI Gene Model | MGI Sequence Detail 2693 C57BL/6J ±  kb
    transcript NM_008274 RefSeq | MGI Sequence Detail 2534 ZRU/MplStud  
    polypeptide P23812 UniProt | EBI | MGI Sequence Detail 268 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      Genomic 9
      cDNA 13
      Primer pair 13
      Other 28

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10854, MGD-MRK-10863, MGD-MRK-10905
    References
    more
    • Summaries
      All 234
      Developmental Gene Expression 146
      Gene Ontology 11
      Phenotypes 80
    • Earliest
      J:21265 Dolle P, et al., Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. Nature. 1989 Dec 14;342(6251):767-72
    • Latest
      J:390509 Huang BL, et al., A pivotal Wnt antagonist role promoting digit joint specification by constraining Wnt activity. Nat Commun. 2026 May 26;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory