Hmga1 MGI Mouse Gene Detail - MGI:96160 - high mobility group AT-hook 1

Symbol

Hmga1
Name

high mobility group AT-hook 1
Synonyms

Hmga1a, Hmga1b, Hmgi, Hmgiy, HMG-I(Y), HMGI(Y), HMGY

Feature Type

protein coding gene
IDs

MGI:96160
NCBI Gene: 15361
Alliance

gene page
Transcription Start Sites

25 TSS

Sequence Map

Chr17:27775471-27782648 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 14.50 cM
Mapping Data

6 experiments

SNPs within 2kb

47 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96160	protein coding gene	Chr17:27774798-27782649 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023421	protein coding gene	Chr17:26869006-26874844 (+)
A/J	MGP_AJ_G0023378	protein coding gene	Chr17:26015036-26025545 (+)
AKR/J	MGP_AKRJ_G0023344	protein coding gene	Chr17:26180266-26186226 (+)
BALB/cJ	MGP_BALBcJ_G0023383	protein coding gene	Chr17:26293562-26300641 (+)
C3H/HeJ	MGP_C3HHeJ_G0023144	protein coding gene	Chr17:26550888-26559234 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023826	protein coding gene	Chr17:27981168-27992931 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021300	protein coding gene	Chr17:23403013-23410089 (+)
CAST/EiJ	MGP_CASTEiJ_G0022645	protein coding gene	Chr17:26499533-26508176 (+)
CBA/J	MGP_CBAJ_G0023118	protein coding gene	Chr17:28943256-28953791 (+)
DBA/2J	MGP_DBA2J_G0023250	protein coding gene	Chr17:25580314-25588137 (+)
FVB/NJ	MGP_FVBNJ_G0023219	protein coding gene	Chr17:25361789-25371376 (+)
LP/J	MGP_LPJ_G0023327	protein coding gene	Chr17:27127835-27138350 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023237	protein coding gene	Chr17:28437784-28446861 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023867	protein coding gene	Chr17:26582147-26592266 (+)
PWK/PhJ	MGP_PWKPhJ_G0022395	protein coding gene	Chr17:24363518-24370814 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022213	protein coding gene	Chr17:24584980-24593367 (+)
WSB/EiJ	MGP_WSBEiJ_G0022708	protein coding gene	Chr17:26572458-26579655 (+)

Human Ortholog

HMGA1, high mobility group AT-hook 1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HMGA1, high mobility group AT-hook 1
Synonyms

HMGA1A, HMGIY, HMG-R
Links

HGNC:5010

NCBI Gene ID: 3159

neXtProt AC: NX_P17096

UniProt: P17096
Chr Location

6p21.31; chr6:34236873-34246231 (+) GRCh38

MGI Vertebrate Homology

Hmga1 stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: HMGA1
Gene Tree

Hmga1

Diseases

4 with Hmga1 mouse models; 1 with human HMGA1 associations

Human Disease

Mouse Models

type 2 diabetes mellitus

IDs

View 2 models

lymphoma

IDs

View 1 model

T-cell acute lymphoblastic leukemia

IDs

View 1 model

uterine cancer

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

3 with disease annotations

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Phenotype Summary

43 phenotypes from 5 alleles in 5 genetic backgrounds
1 phenotype from multigenic genotypes
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

43
Endonuclease-mediated

5
Gene trapped

28
Radiation induced

1
Targeted

8
Transgenic

1
Genomic Mutations

1 involving Hmga1
Incidental Mutations

CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Although haploinsufficiency at this locus is not compatible with germline transmission of one allele at this locus, mice homozygous for two other disruptions are fertile. Abnormalities are seen in glucose metabolism and in the cardiovascular system.

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All GO Annotations

94
GO References

20

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1425
Tissues

265
cDNA Data

22
Literature Summary

27

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN hmga1a

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All Sequences

210
RefSeq

126
UniProt

1
CCDS

CCDS28564.1, CCDS50044.1, CCDS89032.1, CCDS89033.1, CCDS89034.1

Ensembl

ENSMUSG00000046711 (Evidence)
NCBI Gene

15361

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046711	Ensembl Gene Model \| MGI Sequence Detail	7178	C57BL/6J	± kb
transcript	ENSMUST00000231866	Ensembl \| MGI Sequence Detail	584	Not Applicable
polypeptide	ENSMUSP00000155966	Ensembl \| MGI Sequence Detail	118	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008628 high mobility group protein HMG-I/HMG-Y

(term hierarchy)

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All nucleic 29

cDNA 25

Primer pair 4

Microarray probesets 4

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MGD-MRK-10796, MGI:2144347

Summaries

All 118

Developmental Gene Expression 27

Diseases 3

Gene Ontology 20

Phenotypes 39
Earliest

J:9471 Johnson KR, et al., Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y). J Biol Chem. 1988 Dec 5;263(34):18338-42
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Hmga1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143323	Chr17:27773554-27773600 (+)	-1,894 bp
Tssr143324	Chr17:27774493-27774502 (+)	-973 bp
Tssr143325	Chr17:27774532-27774577 (+)	-916 bp
Tssr143326	Chr17:27774609-27774620 (+)	-856 bp
Tssr143327	Chr17:27774790-27774808 (+)	-672 bp
Tssr143328	Chr17:27774825-27774839 (+)	-639 bp
Tssr143329	Chr17:27775554-27775567 (+)	90 bp
Tssr143330	Chr17:27775575-27775586 (+)	110 bp
Tssr143331	Chr17:27775587-27775609 (+)	127 bp
Tssr143332	Chr17:27775617-27775626 (+)	151 bp
Tssr143333	Chr17:27775651-27775664 (+)	187 bp
Tssr143334	Chr17:27775680-27775691 (+)	215 bp
Tssr143335	Chr17:27775735-27775753 (+)	273 bp
Tssr143336	Chr17:27775775-27775788 (+)	311 bp
Tssr143337	Chr17:27775817-27775832 (+)	354 bp
Tssr143338	Chr17:27775847-27775859 (+)	382 bp
Tssr143339	Chr17:27775894-27775906 (+)	429 bp
Tssr143340	Chr17:27775916-27775937 (+)	456 bp
Tssr143341	Chr17:27775951-27775963 (+)	486 bp
Tssr143342	Chr17:27776435-27776481 (+)	987 bp
Tssr143343	Chr17:27776872-27776889 (+)	1,410 bp
Tssr143344	Chr17:27780280-27780289 (+)	4,814 bp
Tssr143345	Chr17:27780314-27780321 (+)	4,847 bp
Tssr143346	Chr17:27780326-27780333 (+)	4,859 bp
Tssr143347	Chr17:27780337-27780351 (+)	4,873 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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